Browsing University of Waterloo by Subject "Proteins"
Now showing items 1-6 of 6
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Characterization of the Distribution of Pyrene Molecules in Confined Geometries with the Model Free Analysis
(American Chemical Society, 2017-12-21)Evidence is provided showing that global Model Free Analysis (MFA) of monomer and excimer fluorescence decays of pyrene dissolved in aqueous solutions of sodium dodecyl sulfate (SDS) provides the same structural and dynamic ... -
Colorimetric Identification of Proteins Using Gold Nanoparticles
(University of Waterloo, 2016-05-31)Proteins are the principal executive biomolecules of life. Their existence is required to drive and regulate countless physiological and biochemical activities within the cell. The study of biochemistry and biology are ... -
Computations to Obtain Wider Tunnels in Protein Structures
(University of Waterloo, 2011-08-29)Finding wide tunnels in protein structures is an important problem in Structural Bioinformatics with applications in various areas such as drug design. Several algorithms have been proposed for finding wide tunnels in a ... -
Construction and analysis of a genetically tuneable lytic phage display system
(Springer, 2013-09-01)The Bacteriophage lambda capsid protein gpD has been used extensively for fusion polypeptides that can be expressed from plasmids in Escherichia coli and remain soluble. In this study, a genetically controlled dual expression ... -
Opposing effects of cationic antimicrobial peptides and divalent cations on bacterial lipopolysaccharides
(American Physical Society, 2017-10-09)The permeability of the bacterial outer membrane, enclosing Gram-negative bacteria, depends on the interactions of the outer, lipopolysaccharide (LPS) layer, with surrounding ions and molecules. We present a coarse-grained ... -
Tracing the molecular and evolutionary determinants of novel functions in protein families
(University of Waterloo, 2010-03-29)This thesis explores the limits of homology-based inference of protein function and evolution, where overall similarity between sequences can be a poor indicator of functional similarity or evolutionary relationships. Each ...