Browsing University of Waterloo by Subject "Proteomics"
Now showing items 1-4 of 4
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The Automation of Glycopeptide Discovery in High Throughput MS/MS Data
(University of Waterloo, 2004)Glycosylation, the addition of one or more carbohydrates molecules to a protein, is crucial for many cellular processes. Aberrant glycosylation is a key marker for various diseases such as cancer and rheumatoid arthritis. ... -
Effective Strategies for Improving Peptide Identification with Tandem Mass Spectrometry
(University of Waterloo, 2011-12-21)Tandem mass spectrometry (MS/MS) has been routinely used to identify peptides from protein mixtures in the field of proteomics. However, only about 30% to 40% of current MS/MS spectra can be identified, while many of them ... -
SPIDER: Reconstructive Protein Homology Search with De Novo Sequencing Tags
(University of Waterloo, 2011-04-21)In the field of proteomic mass spectrometry, proteins can be sequenced by two independent yet complementary algorithms: de novo sequencing which uses no prior knowledge and database search which relies upon existing protein ... -
Supplementation Strategies for Tuning Glycosylation of Monoclonal Antibodies and Enhancing Growth in Mammalian Cell Culture by Omics Analysis
(University of Waterloo, 2018-04-17)Two fundamental objectives of bioprocess engineering are to increase productivity and improve product quality. Glycosylation is a critical and variable factor in the quality of several therapeutic proteins, particularly ...