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Browsing University of Waterloo by Supervisor "Burkowski, Forbes"
Now showing items 1-2 of 2
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Modelling Allostery using a Computational Analysis of Side-Chain Interactions
(University of Waterloo, 2022-09-30)Allostery refers to the regulation of protein activity arising from an effector molecule, such as a ligand, binding to a protein. The exact mechanisms that take place in allosteric regulation are still a source of debate ... -
Protein Structure Elastic Network Models and the Rank 3 Positive Semidefinite Matrix Manifold
(University of Waterloo, 2019-01-09)This thesis is a contribution to the study of protein dynamics using elastic network models (ENMs). An ENM is an abstraction of a protein structure where inter-atomic interactions are assumed to be modelled by a Hookean ...