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dc.contributor.authorZhang, Xu
dc.contributor.authorServos, Mark R.
dc.contributor.authorLiu, Juewen
dc.date.accessioned2017-03-03 15:29:36 (GMT)
dc.date.available2017-03-03 15:29:36 (GMT)
dc.descriptionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemistry Society copyright © American Chemical Society after peer review and technical editing by publisher. To access the final edited and published work see Zhang, X., Servos, M. R., & Liu, J. (2012). Ultrahigh Nanoparticle Stability against Salt, pH, and Solvent with Retained Surface Accessibility via Depletion Stabilization. Journal of the American Chemical Society, 134(24), 9910–9913. https://doi.org/10.1021/ja303787een
dc.description.abstractFor many applications, it is desirable to stabilize colloids over a wide range of buffer conditions while still retaining surface accessibility for adsorption and reaction. Commonly used charge or steric stabilization cannot achieve this goal since the former is sensitive to salt and the latter blocks the particle surface. We use depletion stabilization in the presence of high molecular weight polyethylene glycol (PEG) to stabilize a diverse range of nanomaterials, including gold nanoparticles (from 10 to 100 nm), graphene oxide, quantum dots, silica nanoparticles, and liposomes in the presence of Mg2+ (>1.6 M), heavy metal ions, extreme pH (pH 1–13), organic solvents, and adsorbed nucleosides and drugs. At the same time, the particle surface remains accessible for adsorption of both small molecules and macromolecules. Based on this study, high loading of thiolated DNA was achieved in one step with just 2% PEG 20 000 in 2 h.en
dc.description.sponsorshipUniversity of Waterloo || Canadian Foundation for Innovation || Ontario Ministry of Research & Innovation || Canadian Institutes of Health Research || Natural Sciences and Engineering Research Council ||en
dc.publisherAmerican Chemical Societyen
dc.titleUltrahigh Nanoparticle Stability against Salt, pH, and Solvent with Retained Surface Accessibility via Depletion Stabilizationen
dcterms.bibliographicCitationZhang, X., Servos, M. R., & Liu, J. (2012). Ultrahigh nanoparticle stability against salt, pH, and solvent with retained surface accessibility via depletion stabilization. Journal of the American Chemical Society, 134(24), 9910-9913.en
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Waterloo Institute for Nanotechnology (WIN)en

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