Browsing Theses by Author "McEneny-King, Alanna"
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Metabolism, transport, and physiologically based pharmacokinetic modelling of novel tacrine derivatives
McEneny-King, Alanna (University of Waterloo, 2015-08-26)Alzheimer’s disease (AD) is the most prevalent form of dementia affecting the elderly population, and its burden is rapidly growing both in Canada and worldwide. As a result, there is a substantial need for more effective ... -
Pharmacokinetic modelling of clinically relevant situations in the treatment of hemophilia A and B
McEneny-King, Alanna (University of Waterloo, 2020-04-03)Hemophilia is a congenital bleeding disorder caused by deficiency of clotting factor VIII (FVIII; hemophilia A) or IX (FIX; hemophilia B). Severe hemophilia patients have less than 1% (or 1 IU/dL) of normal factor activity, ...