Browsing Theses by Author "Da Costa, Jason B."
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Catalytic Potential and Ligand Binding Properties of the Malachite Green RNA Aptamer
Da Costa, Jason B. (University of Waterloo, 2008-09-18)The malachite green aptamer was originally engineered for binding specificity to malachite green (MG). The environment inside the aptamer’s electronegative binding pocket was previously harnessed to catalyze an ester ... -
Exploring Ligand Structure and Thermodynamics of the Malachite Green RNA Aptamer
Da Costa, Jason B. (University of Waterloo, 2012-01-20)RNA aptamers are in vitro sequences of RNA that have a high affinity for their target ligand. They have applications in therapeutics, biosensors and molecular machines. While the practical applications of aptamers are ...