Browsing Theses by Title
Now showing items 12570-12589 of 15628
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The role of phospholamban (PLN) in potential protection of sarc(endo)plasmic reticulum Ca2+-ATPase (SERCA) against oxidative stress
(University of Waterloo, 2015-01-23)Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) sequesters Ca2+ from the cytosol to: i) aid in muscular relaxation and ii) refill SR Ca2+ stores for release upon subsequent stimulus for contraction. SERCA function is ... -
The Role of Phospholamban and Sarcolipin in Skeletal Muscle Disease
(University of Waterloo, 2016-01-19)Sarcolipin (SLN) and phospholamban (PLN) are two small proteins that physically interact with and inhibit the sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) pump. Results from our laboratory and others have shown that, ... -
Role of PINCH during early Xenopus embryogenesis
(University of Waterloo, 2012-08-31)In the Xenopus embryo, cell rearrangements during early development require the dynamic modulation of adhesion. Cells primarily use the integrin family of transmembrane receptors for attachment to and interpretation of the ... -
The Role of Practical Reasoning and Typification in Consumer Analytics Work: An Ethnomethodological Study
(University of Waterloo, 2016-07-07)Traditional scholarship views quantitative people-categorization in the workplace—i.e. the use of big data to group consumers and categorize their cultures—as primarily a problem of technical and statistical optimization. ... -
Role of Prolyl 4-Hydroxylase in Pancreatic ß-cell Insulin Secretion
(University of Waterloo, 2017-08-30)Type 2 diabetes mellitus (T2D) is characterized by chronic hyperglycemia and peripheral insulin resistance. In response to elevated blood glucose levels, pancreatic β-cells release insulin which occurs in a biphasic ... -
The Role of Psychological Distance in Forgiveness
(University of Waterloo, 2016-01-20)My aim in the present research was to expand the literature on how to promote forgiveness by considering the role of psychological distance. Participants responded to interpersonal conflict vignettes in six experiments. ... -
The Role of Regulatory Focus Motivation in Experiencing Relationship Success
(University of Waterloo, 2019-04-26)Successful close relationships lie at the heart of people’s health and happiness. Relationship science has argued for several critical relationship qualities that are essential for the maintenance and well-being of romantic ... -
The Role of Restaurants in an Evolving Mid-Size City
(University of Waterloo, 2017-09-27)Mid-sized Canadian cities are witnessing a fundamental shift in the way their downtowns are being utilized and in the role their downtowns play in the broader urban context. These cities (populations 50,000-500,000) have ... -
The Role of Sarcolipin in Calcium Handling and Obesity
(University of Waterloo, 2010-05-19)Sarcolipin (SLN), a small molecular weight, hydrophobic protein found in skeletal muscle, is a known regulator of sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pumps. Earlier in vitro reconstitution experiments have ... -
The Role of Sarcolipin in Muscle Adaptation with Aging
(University of Waterloo, 2024-04-08)The sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) pump facilitates the transport of Ca2+ against a concentration gradient from the cytosol to the lumen of the SR, eliciting relaxation and maintaining Ca2+ homeostasis. ... -
ROLE OF SECOND MESSENGER SIGNALING PATHWAYS IN THE REGULATION OF SARCOPLASMIC RETICULUM CALCIUM-HANDLING PROPERTIES IN THE LEFT VENTRICLE AND SKELETAL MUSCLES OF DIFFERENT FIBRE TYPE COMPOSITION
(University of Waterloo, 2007-02-09)The overall objective of this thesis was to examine mechanisms involved in the acute regulation of sarcoplasmic reticulum (SR) Ca2+-handling properties by second messenger signaling pathways in skeletal and cardiac muscle. ... -
The role of self-esteem and agreeableness in self-reported capitalization outcomes
(University of Waterloo, 2015-08-26)Variation in self-esteem and agreeableness may determine who benefits most from capitalization. The present study investigated the role of self-esteem and agreeableness in capitalization processes in romantic relationships. ... -
The Role of Social Capital in Community-Based Urban Solid Waste Management: Case Studies From Ibadan Metropolis, Nigeria
(University of Waterloo, 2012-07-31)Urban solid waste management (USWM) problems facing cities in the developed and developing world are well documented; however, progress in tackling them is very slow in the latter. There are still many communities, ... -
The role of social information in infants’ and toddlers’ linguistic representations
(University of Waterloo, 2017-07-31)In seven experiments I demonstrate that social group information plays a role in infants’ and toddlers’ speech processing. In Chapter 2, I provide evidence that 16-month-old infants index social information to their ... -
The role of social preferences in the organization of a gregarious mammal colony
(University of Waterloo, 2022-12-02)Social preferences are often demonstrated to exist in “intelligent”, long-lived species, such as cetaceans and primates, where individuals have the opportunity to form relationships with conspecifics through repeated ... -
The role of sodium and calcium permeable T-type channels in generating pacemaking currents in invertebrates
(University of Waterloo, 2016-09-27)T-type calcium channels (Cav3) play a key role in generating rhythmic action potentials in excitable cells such as the heart pacemaker and sleep-wake cycles in the thalamus. T-type channels are low voltage-activated ... -
The Role of Stereopsis in the Control of Grasp Forces during Prehension
(University of Waterloo, 2020-05-28)Background: Binocular viewing is associated with a superior prehensile performance, which is particularly evident in the latter part of the reach as the hand approaches and makes contact with the target object. However, ... -
The role of submersed macrophytes in river eutrophication and biogeochemical nutrient cycling
(University of Waterloo, 2012-09-28)The goal of this work is to contribute to the understanding eutrophication in large rivers with a detailed study of the Grand River, an impacted river in highly agricultural and urbanized Southern Ontario. It focuses on ... -
Role of Symmetry in Hisactophilin Folding
(University of Waterloo, 2009-02-23)Hisactophilin is a histidine-rich actin binding protein from Dictyostelium discoideum; it is a member of the β-trefoil superfamily and exhibits a characteristic tertiary structure with three-fold symmetry. The effect of ... -
The Role of the Group Environment in Galaxy Evolution
(University of Waterloo, 2010-08-11)The majority of typically sized galaxies in the local Universe reside in a common dark matter halo with other similar galaxies known as a galaxy group. However, this was not always the case. Nine billion years ago, when ...