Browsing Theses by Subject "Autophagy"
Now showing items 1-6 of 6
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Autophagy Regulates the NOTCH Signaling Pathway During Skeletal Muscle Cell Differentiation
(University of Waterloo, 2021-06-01)Research has indicated a crucial role for autophagy during skeletal muscle differentiation. More so, the inhibition of autophagy using 3MA (3-methyladenine), CQ (chloroquine), and shRNA against Atg7 has been shown to impair ... -
The Effects of Autophagic Deficiencies on the Leukemia Mitochondrial Phenotype and Implications in Strategic Drug Targeting
(University of Waterloo, 2016-12-13)Acute myeloid leukemia (AML) is a cancer that develops when hematopoietic stem cells in the bone marrow transform into malignant cells and subsequently grow and replicate aberrantly. Autophagy, a pathway by which cellular ... -
Examining the Role of Autophagy in Skeletal Muscle Cell Death and Differentiation
(University of Waterloo, 2015-01-08)Autophagy is catabolic process which sequesters large portions of cytoplasm as well as selected organelles and proteins for degradation. Recently, autophagy has been a topic of much debate owing to conflicting evidence ... -
The Genetic Analysis of Autophagy-Dependent Caspase Activation in Drosophila melanogaster
(University of Waterloo, 2009-10-23)During Drosophila melanogaster pupation, groups of undifferentiated adult cells proliferate and undergo regulated cell shape changes, while larval tissues are eliminated by programmed cell death (PCD). PCD is most commonly ... -
Interplay between Autophagy and Apoptosis During Skeletal Muscle Differentiation
(University of Waterloo, 2020-07-07)Our previous studies showed that autophagy regulates apoptosis and is required for proper skeletal muscle differentiation. Previously, we inhibited autophagy in C2C12 cells using 3MA (3-methyladenine) treatment or shRNA ... -
Math and the Fountain of Youth
(University of Waterloo, 2020-12-10)Ageing is associated with impairments in a number of regulatory processes, including in energy dysregulation that affects multiple metabolic pathways and in the circadian rhythms. In the management of metabolic stress ...