Browsing Theses by Subject "Gene delivery"
Now showing items 1-5 of 5
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Characterization of gemini nanoparticle assembly by fluorescence correlation spectroscopy
(University of Waterloo, 2014-01-23)Research in the field of non-viral gene delivery has demonstrated that a deeper understanding of the fundamental processes of nanoparticle assembly is required in order to improve their efficacy. While gemini nanoparticles ... -
Design and Characterization of Various Lipid, Polymer, and Gemini-Surfactant – Based Vectors and DNA as Non-Viral Delivery Systems for Gene Therapy Applications
(University of Waterloo, 2023-08-31)The bulk of this thesis work is the result of a pharmaceutical collaboration, and it utilizes several proprietary systems. While Chapters 3 and 4 will provide an in-depth discussion of the results, the specific names, ... -
Improving the delivery and immunogenicity of an inhalable CpG-ODN DNA vaccine by bio-adhesive gemini nanoparticles in neonatal chickens
(University of Waterloo, 2018-01-05)Cytosine-phosphodiester-guanine oligodeoxynucleotides (CpG-ODN) are nucleotide sequence motifs found in the bacterial genome that activate the mammalian innate immune response and have been found to boost humoral immunity ... -
Nanoscale physics of surfactant gene delivery
(University of Waterloo, 2016-01-18)Medicine has met a revolution in the expansion of possibilities for therapy based upon synthetic gene delivery. Imagine the ability to correct problems of a genetic origin with a simple drug -- such science fiction fantasies ... -
Synthesis and Characterization of Dissymmetric Gemini Surfactants for Gene Delivery Application
(University of Waterloo, 2016-08-29)The lack of safe and efficient gene- delivery methods has been constantly a limiting obstacle to human gene therapy. Viral vectors have been superior in delivering exogenous DNA or RNA into a foreign cell due to their ...