Browsing Theses by Subject "mitochondrial morphology"
Now showing items 1-2 of 2
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Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products
(University of Waterloo, 2009-04-27)The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty ... -
Investigation of a potential therapeutic role for N-oleoylethanolamide and N-linoleoylethanolamide using lymphoblasts deficient in Tafazzin
(University of Waterloo, 2020-09-01)Barth syndrome (BTHS) is a rare X-linked genetic disorder caused by mutations in the TAZ gene that encodes for a cardiolipin (CL) remodelling enzyme, Tafazzin. Due to an inability to remodel the fatty acyl chains on CL ...