Browsing Theses by Supervisor "Choh, Vivian"
Now showing items 1-5 of 5
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Can kynurenic acid cause myelin loss in chicken optic nerves?
(University of Waterloo, 2017-09-27)Kynurenic acid (KYNA) is one of many kynurenine intermediate products in the tryptophan metabolism pathway and has been shown to have neuro-activity. Previous work revealed that prolonged infusion of a high dose of KYNA ... -
The Development of an Antibody-Drug Conjugate to Specifically Target and Soften the Crystalline Lens in vivo
(University of Waterloo, 2017-04-04)Helmholtz’s classical theory of accommodation states that, within the eye, contraction of the annular ciliary muscle releases the passive tension of zonules that hold the lens in a flattened state. As a result, the surface ... -
Effects of ML-7 on the Actomyosin Networks of the Avian Crystalline Lens
(University of Waterloo, 2022-04-29)Assemblies of contractile proteins such as actin, myosin and myosin light chain kinase (MLCK) are found on the posterior surface of the lens fibre cells. The mechanical properties of chicken lenses, as well as their focal ... -
Effects of Temperature on the Proliferation of Human and Fish Lens Epithelial Cells
(University of Waterloo, 2019-08-29)Crystallins are proteins that confer refractive properties to the crystalline lens. All vertebrate lenses contain α- and β-crystallins, and often a third major crystallin. Crystallins can have additional non-refractive ... -
Electrophysiological measures of optic nerve function
(University of Waterloo, 2021-08-26)The contribution of retinal ganglion cells (RGCs) to human electroretinograms (ERGs) is known, but that of chicken (Gallus gallus domesticus) is not clear. This project seeks to determine the effect of RGC dysfunction on ...