Browsing Theses by Supervisor "Joseph, Jamie"
Now showing items 1-2 of 2
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Isoform-specific Roles of Prolyl-Hydroxylases in the Regulation of β-cell Insulin Secretion during Diet-Induced Obesity in Males
(University of Waterloo, 2024-06-13)Type 2 diabetes affects approximately 480 million individuals worldwide and is associated with impaired tissue insulin sensitivity and β-cell dysfunction. Although there has been much research into nutrient-regulated insulin ... -
Role of Prolyl 4-Hydroxylase in Pancreatic ß-cell Insulin Secretion
(University of Waterloo, 2017-08-30)Type 2 diabetes mellitus (T2D) is characterized by chronic hyperglycemia and peripheral insulin resistance. In response to elevated blood glucose levels, pancreatic β-cells release insulin which occurs in a biphasic ...