Browsing Theses by Supervisor "Reed, Bruce"
Now showing items 1-3 of 3
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Investigating the Use of CRISPR/Cas9 for Genetic Screens in Drosophila
(University of Waterloo, 2021-02-24)The CRISPR/Cas9 system has been adapted into a powerful tool for genetic research. The ability to target regions of a genome in a highly specific manner with a reprogrammable guide RNA has been used in a variety of ... -
Investigating the use of enhancer trapping and Cas9-induced rearrangements to characterize cis-regulatory elements in the Drosophila gene hindsight
(University of Waterloo, 2022-08-22)The gene hindsight (hnt) encodes a transcription factor that is essential for all stages of Drosophila development. Expression of hnt has been observed to promote cell specialization and differentiation of several cell ... -
The role of hindsight in the transient stem cell niche of the Drosophila melanogaster larval midgut
(University of Waterloo, 2018-04-30)The composition of the larval Drosophila midgut includes cells known as adult midgut precursors (AMPs) that represent the founder cells for the adult midgut. During the first and second larval instar stages, AMPs are ...