Browsing Kinesiology and Health Sciences by Title
Now showing items 211-230 of 466
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Examination of Voluntary Wheel Running and Skeletal Muscle Metabolism in the Sarcolipin Knock-Out Mouse
(University of Waterloo, 2012-01-19)Sarcolipin (SLN) is a small sarcoplasmic reticulum (SR) integral membrane protein that regulates the SR Ca2+-ATPase (SERCA). Previous studies indicate that the functional interaction between SLN and SERCA is thermogenic ... -
Examining Autophagy and Mitophagy as Inducible Mechanisms of Cellular Remodelling
(University of Waterloo, 2017-11-20)Despite an explosion of knowledge regarding the molecular regulation of autophagy since its initial characterization in yeast in the 1990s (including the 2016 Nobel Prize in Physiology or Medicine for Dr Yoshinori Ohsumi), ... -
Examining behavioural and electrophysiological markers of mental workload in individuals with and without a history of concussion
(University of Waterloo, 2021-08-19)Objectives: The goal of this thesis was to examine the neurocognitive mechanisms of mental workload for the purpose of improving our knowledge of the long-term effects of concussion. Four experiments were performed ... -
Examining changes in intradiscal pressure during intervertebral disc herniation
(University of Waterloo, 2013-09-27)Background: Approximately 40% of low back pain cases are attributed to internal disc disruption. Since mechanical loading directly affects intradiscal pressure and the stresses that the inner annulus fibrosus experiences, ... -
Examining the Effect of Parvalbumin Overexpression on the Development of Centronuclear Myopathy in Phospholamban Overexpressing Mice
(University of Waterloo, 2022-05-18)Within the myofibre, the sarco(endo)plasmic reticulum (SR) Ca2+ ATPase (SERCA) has an essential role in regulating intracellular Ca2+ concentrations ([Ca2+]i) by pumping Ca2+ into the SR. There are several known regulators ... -
Examining the effects of a passive upper extremity exoskeleton on shoulder fatigue during a simulated automotive overhead weld inspection task
(University of Waterloo, 2024-04-26)Exoskeletons are emerging as occupational assistive devices, and in particular passive upper extremity exoskeletons have been implemented in workplaces in situations where it is not possible to remove overhead work job ... -
Examining the effects of aerobic exercise and bilateral movement on frontal alpha asymmetry
(University of Waterloo, 2016-04-29)Determining the effects of different interventions on brain activity related to depression is imperative to prevention and treatment of the disorder. One measure of brain activity related to depression, called “frontal ... -
Examining the Effects of Exogenous Ketones on Exercise Metabolism and Performance in Male Varsity Athletes
(University of Waterloo, 2018-05-24)Previous research has shown that administration of exogenous acetoacetate (AcAc), beta-hydroxybutyrate (BHB) and glucose in a perfused rodent heart model can increase cardiac output while reducing oxygen uptake compared ... -
Examining the Neuromuscular and Mechanical Characteristics of the Abdominal Musculature and Connective Tissues: Implications for Stiffening the Lumbar Spine
(University of Waterloo, 2008-04-30)Research has uncovered an essential role of proper abdominal muscle function in ensuring the health and integrity of the lumbar spine. The anatomical arrangement of the abdominal musculature (rectus abdominis, external ... -
Examining the Relationship Between Whole Body Resting Metabolic Rate and the Efficiency of SR Ca2+ Handling in Human Skeletal Muscle
(University of Waterloo, 2011-08-26)The purpose of this study was to investigate whether skeletal muscle sarcoplasmic reticulum (SR) Ca2+ transport efficiency and expression levels of major SR Ca2+ regulatory proteins are associated with resting metabolic ... -
Examining the Role of Apoptotic Cell Signalling and Mitochondrial Fisson During Skeletal Muscle Differentiation
(University of Waterloo, 2012-09-28)Cellular maturation (differentiation) and cell death (apoptosis) are two vital processes shared by virtually all mammalian cells types. Although these two events have disparate outcomes, recent evidence indicates their ... -
Examining the role of autophagy and mitophagy in regulating muscle differentiation
(University of Waterloo, 2019-05-22)Autophagy is a degradative process that is used to eliminate intracellular organelles and protein aggregates. Further, a selective form of autophagy, termed mitophagy, is used to specifically degrade mitochondria. ... -
Examining the role of autophagy in modulating apoptotic signaling and skeletal muscle recovery after cardiotoxin injury in tamoxifen-inducible, skeletal muscle-specific Atg7 knockdown mice
(University of Waterloo, 2015-10-06)Skeletal muscle is a unique tissue composed of multinucleated, post-mitotic fibers. Despite its post-mitotic nature, skeletal muscle has an astounding ability to regenerate after injury largely thanks to muscle-specific ... -
Examining the Role of Autophagy in Skeletal Muscle Cell Death and Differentiation
(University of Waterloo, 2015-01-08)Autophagy is catabolic process which sequesters large portions of cytoplasm as well as selected organelles and proteins for degradation. Recently, autophagy has been a topic of much debate owing to conflicting evidence ... -
Examining the role of caspase-2 in skeletal muscle cell differentiation
(University of Waterloo, 2016-09-26)Prior research has indicated a crucial role for apoptotic signaling in skeletal muscle cell differentiation. Although a number of caspases (-3, -8, -9) have been implicated in this process, few prior investigations have ... -
Examining the Role of DNM1L-Dependent Mitochondrial Fission and Mitophagy Receptors During Skeletal Muscle Differentiation
(University of Waterloo, 2020-07-27)Mitochondrial fission is necessary for the remodelling of existing mitochondria during skeletal muscle differentiation. When there is a need for muscle regeneration or repair, stem cell-like myoblasts exit the cell cycle, ... -
Exercise, Shear Stress, and Flow-Mediated Dilation of Human Conduit Arteries
(University of Waterloo, 2009-12-22)Flow-mediated dilation (FMD) refers to the relaxation of vascular smooth muscle and the subsequent dilation of the vessel in response to increases in shear stress on the endothelial lining accompanying increases in blood ... -
An Exploration of Residents' and Care Partners' Perspectives on 3D Printed Pureed Food in Long-Term Care Homes in Ontario
(University of Waterloo, 2019-09-30)Dysphagia, or swallowing difficulties, results in the inability to consume foods of regular texture and/or fluids of regular consistency. A large proportion of residents in long term-care (LTC) homes in Ontario suffer from ... -
Exploring Differences in Vascular Aging and Cerebrovascular Hemodynamics between Older Adults of White Caucasian and South Asian Origin
(University of Waterloo, 2014-09-23)In Canada, the number of older adults has been on the rise over the past several decades. As the aging population continues to rise, the prevalence of chronic illnesses is projected to correspondingly increase at an ... -
Exploring End-of-Life Nutrition Care for Residents of Long-Term Care: A Retrospective Chart Review
(University of Waterloo, 2023-08-22)Introduction: Eating challenges are prevalent in long-term care (LTC) and have been associated with mortality, particularly in older adults with advanced conditions such as dementia. However, changes to eating habits and ...