Browsing Kinesiology and Health Sciences by Title
Now showing items 287-306 of 466
-
The Influence of the Tensile Material Properties of Single Annulus Fibrosus Lamellae and the Interlamellar Matrix Strength on Disc Herniation and Progression
(University of Waterloo, 2009-07-30)Low back pain is highly prevalent in the developed world, with 80% of the population being affected at some point in their lives. Herniation, a common injury to the intervertebral disc, is characterized as the posterior ... -
Interplay between Autophagy and Apoptosis During Skeletal Muscle Differentiation
(University of Waterloo, 2020-07-07)Our previous studies showed that autophagy regulates apoptosis and is required for proper skeletal muscle differentiation. Previously, we inhibited autophagy in C2C12 cells using 3MA (3-methyladenine) treatment or shRNA ... -
Intervertebral Disc Height Loss and Restoration: Outcomes and Implications
(University of Waterloo, 2016-01-18)This thesis is unified around the theme of disc height loss. Current knowledge in the area of spine research identifies mechanical overload as the culprit for the initiation of injury to the spine. While genetic ... -
Intra- and interhemispheric cortical adaptations due to modulations of premotor and primary motor cortices
(University of Waterloo, 2014-02-21)Movement training modulates the excitability in several cortical and subcortical areas. Compared to training with a single arm, movement training with both arms yields a greater increase in motor related cortical regions. ... -
Investigating cerebellar contributions to sensory processing
(University of Waterloo, 2020-04-21)Over the last two decades, the long-standing view of the cerebellum as a motor structure has been challenged with evidence highlighting the presence of cerebellar activation during non-motor tasks and functional connectivity ... -
Investigating cerebellar modulation of premotor inhibitory control during motor adaptation
(University of Waterloo, 2022-08-02)Motor adaptation is marked by neurophysiological changes in the motor cortex; however, other regions of the motor network such as the cerebellum and premotor cortex also contribute to this process. Enhancing cerebellar ... -
Investigating if Motor Preparation Enhances Visuomotor Associative Neuroplasticity
(University of Waterloo, 2018-09-04)The human brain is known to be highly adaptive which has important implications for motor learning and recovery from neurologic injury. It has been shown that long term potentiation-like neuroplasticity can be experimentally ... -
Investigating the Association Between Enhancements in Perceptual Sensitivity to Object Form and Reach to Grasp Performance
(University of Waterloo, 2017-12-11)The act of reaching to grasp an object serves as a primary method of interaction with the surrounding environment. Therefore, it is important to understand the association between perceptual sensitivity to object form and ... -
Investigating the attentional effects of acute aerobic exercise and crossmodal processing on the modulation of frontoparietal interactions
(University of Waterloo, 2015-01-06)The sense of touch commences when afferent sensory signals from the periphery ascend via the spinal cord to the cortex. At the cortical level, incoming peripheral signals are susceptible to neuronal modulation at the ... -
Investigating the effects of exercise on attentional correlates in those with a history of concussion
(University of Waterloo, 2021-06-02)The current understanding of changes that occur neurophysiologically and neurocognitively in the brain following concussion are considerably debated among researchers. Even more largely debated are the long-lasting changes ... -
Investigating the efficacy of the NASA fluid loading protocol for astronauts: The role of hormonal blood volume regulation in orthostasis after bed rest
(University of Waterloo, 2009-08-05)Despite years of research, the role that hypovolemia plays in orthostatic intolerance after head down bed rest (BR) and spaceflight remains unclear. Additionally, the efficacy of oral saline countermeasures, employed in ... -
Investigating the Importance of RAB7 in C2C12 Myoblast Differentiation
(University of Waterloo, 2021-06-01)Prior research has shown that autophagy and mitophagy are intimately linked to skeletal muscle differentiation and myogenesis. Recent studies show that the RAB7 cycle is crucial in multiple stages of autophagy and mitophagy; ... -
Investigating the long-term effects of concussion on sensory gating
(University of Waterloo, 2018-01-08)The prefrontal cortex (PFC) is a brain region critical for an abundance of neural processes. A vast amount of research employing both behavioural and neurophysiological methods has demonstrated significant impairments in ... -
Investigating the role of task intensity on motor unit fatigue recovery
(University of Waterloo, 2023-01-05)Background: It is unclear how the intensity as well as the underlying contributions of larger versus smaller motor units of a performed task impacts fatigue recovery. Therefore, I tested two hypotheses: that the normalized ... -
Investigation of a Double Calibration Technique to Reduce Soft Tissue Artifact Error in High Flexion
(University of Waterloo, 2022-02-01)High knee flexion tasks (knee flexion angle > 120 degrees) are performed frequently in both daily living activities (gardening, religious practice, exercise, etc.) and occupational settings (childcare, roofing, construction, ... -
Investigation of a potential therapeutic role for N-oleoylethanolamide and N-linoleoylethanolamide using lymphoblasts deficient in Tafazzin
(University of Waterloo, 2020-09-01)Barth syndrome (BTHS) is a rare X-linked genetic disorder caused by mutations in the TAZ gene that encodes for a cardiolipin (CL) remodelling enzyme, Tafazzin. Due to an inability to remodel the fatty acyl chains on CL ... -
Investigation of Hand Forces, Shoulder and Trunk Muscle Activation Patterns and EMG/force Ratios in Push and Pull Exertions
(University of Waterloo, 2010-09-30)When designing work tasks, one goal should be to enable postures that maximize the force capabilities of the workers while minimizing the overall muscular demands; however, little is known regarding specific shoulder tissue ... -
An Investigation of Methods to Attenuate Soft Tissue Artifact of the Thigh in High Knee Flexion
(University of Waterloo, 2020-08-26)Soft tissue artifact during optical motion capture, or the movement of skin markers relative to bone, is widely accepted as a significant source of error in estimations of angles and moments. In some cases, the error ... -
An investigation of the biomechanical factors influencing knee joint function following total knee replacement
(University of Waterloo, 2009-12-22)Knee replacement surgery is often performed in cases where the pain due to knee osteoarthritis can no longer be effectively controlled by conservative measures. The surgery—which replaces the articular surfaces of the ... -
An Investigation of the Role of Dynamic Axial Torque on the Disc Herniation Mechanism
(University of Waterloo, 2008-08-19)Background: Disc herniations are common and have been demonstrated as one potential source of low back pain. To date epidemiological studies have found associations between lifting, lifting and twisting and twisting with ...