Browsing Kinesiology and Health Sciences by Type "Doctoral Thesis"
Now showing items 21-40 of 127
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Characterizing the Roles of Myoregulin and Dwarf Open Reading Frame in Regulating Calcium Homeostasis in Muscle
(University of Waterloo, 2024-01-26)The sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs) are responsible for inducing muscle relaxation and are integral to the maintenance of intracellular calcium (Ca2+) homeostasis. As such, their activity is modulated ... -
Cognitive control, conflict monitoring, and aerobic exercise.
(University of Waterloo, 2018-05-01)Cognitive control includes a subset of top-down cognitive functions that allow flexible goal-directed behaviour that are often impaired in people with mental illness and in older adults. Even in healthy individuals, cognitive ... -
A combined in vivo and in vitro approach to assess supraspinatus activation and tissue responses to arm elevation demands
(University of Waterloo, 2020-01-22)Rotator cuff degeneration affects a large portion of the human population, yet knowledge surrounding which loading scenarios allow transition from healthy to diseased states remains largely unresolved. Mechanistic progression ... -
A Comprehensive Assessment of Nutritional Status and Factors Impacting Nutrition Recovery in Hospitalized, Critically Ill Patients Following Liberation from Mechanical Ventilation
(University of Waterloo, 2017-05-19)Disease related malnutrition is a concern for the critically ill, however there is a paucity of research examining nutrition recovery in survivors of critical illness. Prior to the development of nutrition interventions ... -
Considerations for Designing and Managing Resistance Training Intervention Studies
(University of Waterloo, 2021-12-10)Background: Osteoporosis is a bone disease characterized by low bone mineral density (BMD) which is strongly associated with an increase in fracture risk. People with a spinal cord injury (SCI) experience rapid decline in ... -
The contribution of the fronto-cerebellar system in cognitive processing
(University of Waterloo, 2013-01-23)Over two decades of patient and neuroimaging data have provided increasing support for a role of the posterior cerebellum in cognition, particularly attention. Contralateral connections between the prefrontal cortex and ... -
Contributors to Proximal Femur Fracture Force: Multiscale Considerations of Rate, Toughness, and Bone Composition
(University of Waterloo, 2022-06-09)Fall-related hip fractures are a major concern facing the older adult population, especially as rates of these injuries increasing worldwide. Based on the strong positive relationship between femoral areal bone mineral ... -
Control of Dynamic Stability during Gait Termination on a Slippery Surface
(University of Waterloo, 2007-01-17)The purpose of this thesis is to investigate the reaction to a purely unexpected slip during gait termination and subsequent experiences stopping on the slippery surface in participants who are young and healthy, older and ... -
Coordination of turning when standing and walking in healthy older adults and persons with Parkinson’s disease
(University of Waterloo, 2008-10-23)It is difficult to think of any activity that does not require some degree of turning. Despite the prevalence of turning in daily activities and the challenge it poses to mobility-impaired individuals such as those with ... -
Cortical activations underlying human bipedal balance control
(University of Waterloo, 2016-10-25)Human bipedal balance is a complex sensorimotor task controlled by the central nervous system. Balance impairments, caused by aging or neuromuscular diseases, often lead to falls which are one of the leading causes of ... -
Cortical and behavioural adaptations induced by bimanual movement training: an electrophysiological study in the healthy population
(University of Waterloo, 2009-09-30)Bimanual movement training (BMT) of the upper extremity has been found to improve sensorimotor function of the stroke affected limb for some patients; however, the neurophysiological mechanism underlying behavioural ... -
Deletion of Sarco(endo)plasmic Reticulum Ca2+-ATPase Regulatory Proteins: Impacts on Energy Metabolism and Obesity
(University of Waterloo, 2017-11-28)The sarco(endo)plasmic reticulum (SR) Ca2+-ATPase (SERCA) is responsible for maintaining low cytosolic [Ca2+] through the ATP-dependent pumping of Ca2+ ions from the cytosol into the SR lumen. SERCA activity has the ... -
Demonstrating relationships between workplace demands and exposures related to musculoskeletal disorders and stress-related health outcomes
(University of Waterloo, 2015-05-15)Musculoskeletal disorders (MSD) and outcomes related to stress, such as mental health disorders, are important sources of pain, distress, disability, and costs in Canadian workplaces. Recent initiatives have highlighted ... -
Determinants And Strategies For The Alternate Foot Placement
(University of Waterloo, 2005)Undesirable landing area (e. g. , a hole, a fragment of glass, a water puddle, etc) creates the necessity for an alternate foot placement planning and execution. Previous study has proposed that three determinants are ... -
Developing measures of muscle health in women diagnosed with breast cancer and in a healthy, young adult reference cohort
(University of Waterloo, 2021-02-12)Skeletal muscle health is an important predictor of survival, treatment toxicity, and physical function in cancer patients and survivors. While accelerated rates of muscle wasting are often observed in patients with advanced ... -
The Development and Assessment of Rapid Methods for Fatty Acid Profiling
(University of Waterloo, 2012-08-29)Fatty acid profiling provides information on dietary intakes and an understanding of lipid metabolism. High throughput techniques such as fingertip prick (FTP) sampling has gained popularity in recent years as a simplified ... -
Development of a full flexion 3D musculoskeletal model of the knee considering intersegmental contact and deep muscle activity during high knee flexion
(University of Waterloo, 2019-01-24)Habitual kneeling in high knee flexion postures is a risk factor for knee joint dysfunction yet critical parameters for modeling this range of motion remain unknown or untested in three dimensions. High flexion is defined ... -
Development of a Neuromechanical Model for Investigating Sensorimotor Interactions During Locomotion
(University of Waterloo, 2010-10-22)Recently it has been suggested that the use of neuromechanical simulations could be used to further our understanding of the neural control mechanisms involved in the control of animal locomotion. The models used to carry ... -
Development of a Probabilistic Chimpanzee Glenohumeral Model: Implications for Human Function
(University of Waterloo, 2018-08-17)Modern human shoulder function is affected by the evolutionary adaptations that have occurred to ensure survival and prosperity of the species. Robust examination of behavioral shoulder performance and injury risk can be ... -
Development of a probabilistic population model for the prediction of subacromial geometric variability
(University of Waterloo, 2015-03-16)Subacromial impingement syndrome (SAIS) is common in the shoulder and precedes several additional pathologies. SAIS occurs when the tissues interposed between the acromion process of the scapula and superior surface of the ...