Browsing Science (Faculty of) by Author "Layton, Anita T."
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Aging affects circadian clock and metabolism and modulates timing of medication
Sadria, Mehrshad; Layton, Anita T. (Elsevier, 2021-04)Aging is associated with impairments in the circadian rhythms, and with energy deregulation that affects multiple metabolic pathways. The goal of this study is to unravel the complex interactions among aging, metabolism, ... -
Impact of sex and pathophysiology on optimal drug choice in hypertensive rats: Quantitative insights for precision medicine
Ahmed, Sameed; Sullivan, Jennifer C.; Layton, Anita T. (Elsevier, 2021-04)Less than half of all hypertensive patients receiving treatment are successful in normalizing their blood pressure. Despite the complexity and heterogeneity of hypertension, the current antihypertensive guidelines are not ... -
Multiscale models of kidney function and diseases
Layton, Anita T. (Elsevier, 2019-09)The kidney is a complex system whose function is the result of synergistic operations among a number of biological processes. The spatial and functional scales of those processes span a wide range. To interrogate kidney ... -
Network centrality analysis of eye-gaze data in autism spectrum disorder
Sadria, Mehrshad; Karimi, Soroush; Layton, Anita T. (Elsevier, 2019-08)Individuals suffering from autism spectrum disorder (ASD) exhibit impaired social communication, the manifestations of which include abnormal eye contact and gaze. In this study, we first seek to characterize the spatial ... -
Sex differences in solute and water handling in the human kidney: Modeling and functional implications
Hu, Rui; McDonough, Alicia A.; Layton, Anita T. (Elsevier, 2021-06)The kidneys maintain homeostasis by controlling the amount of water and electrolytes in the blood. That function is accomplished by the nephrons, which transform glomerular filtrate into urine by a transport process mediated ...