Browsing Science (Faculty of) by Title
Now showing items 331-350 of 3044
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Characterization of Cadmium-Induced BiP Accumulation in Xenopus laevis A6 Kidney Epithelial Cells
(University of Waterloo, 2016-08-19)In vertebrates, cadmium exposure is found to cause respiratory, neurological and kidney disorders. At the cellular level, cadmium can damage or modify proteins resulting in the production of toxic protein aggregates. The ... -
The characterization of checkpoint kinase 2 in Oncorhynchus mykiss: Tissue specific expression suggests biomarker potential
(University of Waterloo, 2007-09-05)Chk2 is a cell cycle checkpoint kinase that is essential for initiating the DNA damage response in the presence of genetic damage. Its role is highly conserved from budding yeast (where it is named Rad53) to humans. Very ... -
Characterization of counterion effects of gemini surfactants and in vitro studies of transfection efficiency for gene therapy in epithelial ovarian cancer.
(University of Waterloo, 2015-01-23)Gene therapy has emerged as a promising strategy for the treatment or prevention of many acquired or genetic diseases that are considered incurable at the present time. Although viral and non-viral vector approaches are ... -
Characterization of daptomycin oligomerization with perylene excimer fluorescence: Stoichiometric binding of phosphatidylglycerol triggers oligomer formation
(Elsevier, 2012-03)Daptomycin is a lipopeptide antibiotic that binds to and depolarizes bacterial cell membranes. Its antibacterial activity requires calcium and correlates with the content of phosphatidylglycerol in the target membrane. ... -
The characterization of Dbf4 interactions and roles in genome replication and stability in Saccharomyces cerevisiae
(University of Waterloo, 2020-03-05)Dbf4-dependent kinase (DDK) is a complex composed of the Cdc7 kinase and its regulatory subunit, Dbf4. Initiation of eukaryotic DNA replication requires phosphorylation of Mcm2-7 helicase by DDK. Due to its essential role ... -
Characterization of Dbf4 structure and function in Saccharomyces cerevisiae DNA replication and checkpoint responses.
(University of Waterloo, 2014-02-21)The Dbf4/Cdc7 kinase complex is required for the initiation of DNA replication and promotes this by acting upon members of the Mcm2-7 helicase. In addition to its role in replication, Dbf4/Cdc7 is a target of the S-phase ... -
Characterization of Detector and Electron Source for Inverse Photoemission Spectrometer
(University of Waterloo, 2023-02-17)The inverse photo-emission spectroscopy (IPES) is a powerful tool to probe the unoccupied energy states of materials, such the surface states of metals or the unoccupied states of high temperature superconductors. IPES ... -
Characterization of Dissolved Organic Matter and Reduced Sulfur in Coastal Marine and Estuarine Environments: Implications for Protective Effects on Acute Copper Toxicity
(University of Waterloo, 2009-05-13)Copper-induced toxicity in aqueous systems depends on its speciation and bioavailability. Dissolved organic matter (DOM) and reduced sulfur species can complex copper, influencing speciation and decreasing bioavailability. ... -
Characterization of Eukaryotic Translation Initiation Factor 5A isoforms (eIF-5A1 & eIF-5A2) using human cell lines as a model system
(University of Waterloo, 2006)Eukaryotic translation initiation factor 5A (eIF-5A) is the only known cellular protein that contains the post-translationally derived amino acid, hypusine. Initially, eIF-5A was named as a translation initiation factor ... -
Characterization of Eukaryotic Translation Initiation Factor 5A-2 (eIF5A-2) in <i>Arabidopsis thaliana</i>: Effects of Wounding and Pathogen Attack
(University of Waterloo, 2004)Plants respond to wounding and pathogen ingress by synthesizing defence proteins that facilitate wound healing, cell death or provide protection against further pathogen attack. The accumulation of these proteins is ... -
Characterization of gate oxides and microwave resonators for silicon spin qubit devices
(University of Waterloo, 2022-01-21)Silicon quantum dots present themselves as a promising implementation for quantum information processing due to the fact that they possess a small chip foot-print, yield high coherence times and are able to leverage the ... -
Characterization of gemini nanoparticle assembly by fluorescence correlation spectroscopy
(University of Waterloo, 2014-01-23)Research in the field of non-viral gene delivery has demonstrated that a deeper understanding of the fundamental processes of nanoparticle assembly is required in order to improve their efficacy. While gemini nanoparticles ... -
Characterization of Genes involved In Development and Senescence
(University of Waterloo, 2006)Plant development is complex and highly regulated. Tens of thousands of genes have been sequenced for the model plant <em>Arabidopsis thaliana</em>, yet few have been functionally annotated and characterized. This ... -
Characterization of glucose oxidation by gold nanoparticles using nanoceria
(Elsevier, 2014-04-30)Gold nanoparticles (AuNPs) can oxidize glucose, producing hydrogen peroxide and gluconic acid, which are the same products as those generated by glucose oxidase (GOx). In this regard, AuNPs are a nanozyme. Herein, a new ... -
Characterization of High-PGE Low-Sulphur Mineralization at the Marathon PGE-Cu Deposit, Ontario
(University of Waterloo, 2013-03-13)The Marathon PGM-Cu deposit is hosted by the Coldwell alkaline complex, which consists predominantly of gabbro and syenite and was emplaced at 1108 Ma as part of the Mid-Continent Rift System. Mineralization at the Marathon ... -
Characterization of HSP47 Expression in <i>Xenopus Laevis</i> Cell Culture and Embryos
(University of Waterloo, 2005)The heat shock or stress response is a transient response to stressful stimuli that protects vital cellular proteins from damage and irreversible aggregation. Heat shock proteins (Hsps) are molecular chaperones that ... -
Characterization of Hydrophobically Modified Starch Nanoparticles by Pyrene Fluorescence
(University of Waterloo, 2017-01-25)Starch nanoparticles (SNPs) were hydrophobically modified with propionic (C3) and hexanoic (C6) anhydride via esterification. Different degrees of substitution (DS) of the hydroxyl groups of the SNPs were achieved by varying ... -
Characterization of iron- and zinc-containing alcohol dehydrogenases from anaerobic hyperthermophiles
(University of Waterloo, 2007-12-18)Hyperthermophiles are microorganisms that can grow at temperatures close to the boiling point of water or above. They are potential resources of thermostable enzymes including alcohol dehydrogenases (ADHs). Both Thermococcus ... -
Characterization of Langmuir-Blodgett Films by Electron Spin Resonance Spectroscopy
(University of Waterloo, 2020-01-15)Langmuir-Blodgett (LB) films built up with amphiphilic molecules have well-known optical, electrical and magnetic properties. For most applications, it is fundamentally important to understand the structure of the films. ... -
Characterization of Lipid Deposition on Contact Lenses
(University of Waterloo, 2017-08-30)The purpose of this thesis was to evaluate the influence of lipid deposition on silicone hydrogel contact lens materials and to construct an in vitro platform to further explore the effect of lipid interaction with contact ...