Browsing Science (Faculty of) by Title
Now showing items 559-578 of 3049
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Coupling solid phase microextraction to complementary separation platforms for metabotyping of E. coli metabolome in response to natural antibacterial agents
(Springer, 2016-11-02)Introduction Essential oils are known to possess antimicrobial activity; thus, their use has played an important role over the years in medicine and for food preservation purposes. Objective The effect of clove oil and its ... -
Covalent linking DNA to graphene oxide and its comparison with physisorbed probes for Hg2+ detection
(Elsevier, 2016-05-15)Graphene oxide (GO) has attracted extensive research interest as a platform for DNA adsorption and biosensor development. While most researchers use simple physisorption of fluorescently labeled DNA, covalent sensors are ... -
Cr3+ Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis
(American Chemical Society, 2017-06-07)The interaction between chromium ions and DNA is of great interest in inorganic chemistry, toxicology, and analytical chemistry. Most previous studies focused on in situ reduction of Cr(VI), producing Cr3+ for DNA binding. ... -
Creating and probing laser-cooled atomic ensembles inside a hollow-core optical fibre
(University of Waterloo, 2024-01-26)A laser-cooled atomic ensemble confined inside a hollow-core optical fiber offers a unique platform for enhanced light-matter interactions and their applications. At the same time, transferring a cloud of laser-cooled ... -
A critical review of solid phase microextraction for analysis of water samples
(Elsevier, 2016-12-01)The review summarizes applications of solid phase microextraction (SPME) for water sample analysis. Official methods and standards of SPME in water research and inter-laboratory validation are discussed. A comparison of ... -
Crystal Structures and Optical Properties of Group 14 Chalcogenides
(University of Waterloo, 2019-09-26)The crystal structures and physical properties of several new tetrel and chalcogenide compounds have been investigated in this thesis. The crystal structures, syntheses, and electronic structures of the three centrosymmetric ... -
Crystallization Studies of Highly Monodisperse Oligomeric Poly(Ethylene Oxide)
(University of Waterloo, 2018-12-13)Poly(ethylene oxide) is one of the most intensively studied polymers in terms of crystallization, because of its linear structure. In this thesis the chapters are organized in a self-contained fashion, with a general ... -
A Curiosity Driven Exploration of Hypervalent Iodine(III) Reagents
(University of Waterloo, 2024-05-27)Hypervalent iodine (HVI) reagents have established themselves in the literature as reagents with diverse reactivity and utility in many different transformations. Their unique bonding structure often leads to divergent ... -
Customized nonlinearity shaping in imperfect or variable waveguides
(University of Waterloo, 2019-05-31)Generation of high-quality single photons via heralded parametric downconversion re- quires careful design of spectral correlations in down-converted photon pairs. One step in this design process involves customized ... -
Cyclic Biamperometry
(University of Waterloo, 2009-08-17)In this thesis, cyclic biamperometry (CB) as a new method in electrochemistry, has been introduced and investigated. The hallmark of this method is the absence of a reference electrode which potentially allows simplification ... -
Cyclobutanone Analogues of β-Lactam Antibiotics as Inhibitors of Serine- and Metallo-β-Lactamases
(University of Waterloo, 2011-05-31)Bacterial resistance to antibiotics is an emerging epidemic throughout the world and there is a desperate need for new antibiotics and new strategies to maintain the effectiveness of current agents. β-Lactams, such as the ... -
Cylindrical colloids on a fluid membrane
(University of Waterloo, 2009-05-22)We theoretically study the adhesion and membrane-mediated interaction of cylindrical colloids to a flat fluid membrane. There are two ways to approach this problem. The first way, based on energy, requires finding the ... -
Cytochrome c Oxidase Deficiency: Study of Aberrant Phenotypes and their Connection to Secondary Functions of Assembly Factors
(University of Waterloo, 2017-12-14)Mitochondria are double membrane-bound organelles present in all eukaryotic organisms and are involved in myriad cellular pathways. Cytochrome c oxidase (COX) is a mitochondrial inner membrane protein complex that is an ... -
Daptomycin forms cation- and size-selective pores in model membranes
(Elsevier, 2014-10)Daptomycin is a lipopeptide antibiotic that is used clinically to treat severe infections caused by Gram-positive bacteria. Its bactericidal action involves the calcium-dependent binding to membranes containing ... -
Daptomycin: Mechanism of Action and Bacterial Resistance
(University of Waterloo, 2015-02-25)Daptomycin is an important lipopeptide antibiotic used for treating severe infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus ... -
Daptomycin: studies on its action mode and on bacterial resistance with model membranes
(University of Waterloo, 2016-05-16)Bacterial resistance to antibiotics is one of the most serious problems facing medicine today. Recently, reports have appeared describing bacteria that are resistant to daptomycin (dap), an important antibiotic used against ... -
Dark Matter and Neutrinos in the Foggy Universe
(University of Waterloo, 2019-01-07)Dark matter is predicted to be the main contribution to the matter content in the universe, in addition to ordinary baryonic matter such as protons and neutrons. However, we are limited in our knowledge of the nature of ... -
Dark Screening of the Cosmic Microwave Background with Hidden-Sector Particles and New Dynamical Observables in First Order Phase Transitions
(University of Waterloo, 2024-07-02)This thesis focuses on two research directions within the field of Cosmology. It comprises the main results of my work as a PhD student. Part~\ref{PartI} introduces new observables of false vacuum decay derived from real-time ... -
Data Analysis Protocol for the Development and Evaluation of Population Pharmacokinetic Models for Incorporation Into the Web-Accessible Population Pharmacokinetic Service - Hemophilia (WAPPS-Hemo)
(JMIR Publications, 2016-12-07)Background: Hemophilia is an inherited bleeding disorder caused by a deficiency in a specific clotting factor. This results in spontaneous bleeding episodes and eventual arthropathy. The mainstay of hemophilia treatment ... -
A Data Mining Approach for Detecting Evolutionary Divergence in Transcriptomic Data
(University of Waterloo, 2019-11-19)It has become common to produce genome sequences for organisms of scientific or popular interest. Although these genome projects provide insight into the gene and protein complements of a species including their evolutionary ...