Browsing Science (Faculty of) by Title
Now showing items 619-638 of 3049
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Design, Synthesis and Biological Evaluation of 2,4-Disubstituted Pyrimidine Derivatives: Multifunctional Candidates as Potential Treatment Options for Alzheimer’s Disease
(University of Waterloo, 2011-08-30)Alzheimer’s disease (AD) is a highly complex and rapidly progressive neurodegenerative disorder characterized by the systemic collapse of cognitive function and formation of dense amyloid-β (Aβ) plaques and neurofibrillary ... -
Design, Synthesis and Biological Evaluation of Novel Adamantane Derivatives as Potential Treatments for Alzheimer’s Disease
(University of Waterloo, 2017-02-14)Alzheimer’s disease (AD) is a complex, multifactorial, and rapidly neurodegenerative disorder characterized by cognitive impairment and progressive dementia. Its pathology was first characterized by Alois Alzheimer as “a ... -
Design, synthesis and biological evaluation of novel tricyclics as dual cholinesterase (ChE) and amyloid aggregation inhibitors with antioxidant properties
(University of Waterloo, 2014-12-12)Alzheimer’s disease (AD) is a complex neurodegenerative disease affecting the cholinergic region of the brain. Its prevalence is steadily increasing and it is becoming one of the highest costing diseases to modern society. ... -
Design, Synthesis and Characterization of a Series of Self-assembling Polypeptides
(University of Waterloo, 2007-05-24)A series of polypeptides with well-defined sequences, (Asp3Phe1)n, (Asp2Phe1)n, (Asp1Phe1)n, (Asp1Phe2)n, and (Asp1Phe3)n, containing the hydrophilic amino acid, aspartic acid (Asp) and the hydrophobic amino acid, phenylalanine ... -
Design, synthesis, and evaluation of inhibitors of steroid sulfatase
(University of Waterloo, 2014-04-22)Steroid sulfatase (STS) catalyzes the desulfation of biologically inactive sulfated steroids to yield biologically active desulfated steroids and is currently being examined as a target for therapeutic intervention for the ... -
Design, Synthesis, and Evaluation of Tacrine-Based Derivatives: Potential Agents to Treat Alzheimer’s Disease
(University of Waterloo, 2013-08-01)With the incidence of Alzheimer’s disease (AD) growing worldwide and in Canada along with the growing economic and social burdens, the need for more effective therapies becomes of great importance. Since the discovery of ... -
Desulfurization Activated Phosphorothioate DNAzyme for the Detection of Thallium
(American Chemical Society, 2015-10-20)Thallium (Tl) is a highly toxic heavy metal situated between mercury and lead in the periodic table. While its neighbors have been thoroughly studied for DNA-based sensing, little is known about thallium detection. In this ... -
A detailed hydrologic evaluation of tile-drained macroporous soils: A field and modelling study
(University of Waterloo, 2011-03-07)The underlying objective of this research is to improve the overall understanding of how spatial and temporal variability in macroporosity and soil hydraulic properties in the shallow subsurface influence the long term ... -
Detecting the effects of biological invasion and subsequent control efforts on wetland ecological processes
(University of Waterloo, 2018-09-21)Meadow and emergent cattail wetland communities in eastern North America are being replaced by an invasive lineage of <i>Phragmites australis</i>. This invasion has consequences for wetland ecosystem functions; including ... -
Detecting the Surface Spin Polarization State of Topological Materials by Using Resonant X-ray Reflectometry
(University of Waterloo, 2019-10-21)The topological insulator as a promising and low cost next generation spintronic device attracts lots of attentions recently. The spin-momentum locking is a characteristic feature of topological materials at the surface ... -
Detection Efficiency Mismatch and Finite-Key-Size Attacks on Practical Quantum Cryptography Systems
(University of Waterloo, 2016-01-14)Security verification for the physical implementation of a cryptography system is an important step to ensure the security level promised by theory. As has been shown many times, any physical device has characteristics and ... -
Detection of Anammox Bacteria in Ammonium-Contaminated Groundwater
(University of Waterloo, 2011-09-30)Anaerobic ammonium-oxidizing (anammox) bacteria perform an important step in the global nitrogen cycle: oxidizing ammonium and reducing nitrite to form dinitrogen gas in the absence of oxygen. Anammox bacteria from the ... -
Detection of Nitroaromatic Compounds through Fluorescence Quenching of Pyrene Labeled Starch Nanoparticles
(University of Waterloo, 2018-12-10)The aim of this research was to demonstrate the potential application of starch nanoparticles (SNPs) labeled with 1-pyrenebutyric acid (PBA) as the active component in optical sensors used for the detection of minute ... -
Detection of Nitroaromatics Using the Excimer Fluorescence of Pyrene-Labeled Starch Nanoparticles
(American Chemical Society, 2019-09-09)Starch nanoparticles (SNPs) were hydrophobically modified using 1-pyrenebutyric acid (PyBA) with degrees of substitution (DS) between 0.0006 and 0.11. Fluorescence quenching studies were conducted on the pyrene-labeled ... -
Detectors, Reference Frames, and Time
(University of Waterloo, 2017-11-08)This thesis is divided into three parts. Part I investigates the behaviour of Unruh-DeWitt detectors on curved spacetimes admitting a Wightman function and the associated measurement model is identified. These detectors ... -
Determination of Geosmin and 2-Methylisoborneol in Fish using In-vivo Solid Phase Microextraction
(University of Waterloo, 2012-08-31)The presence of off-flavor compounds in fish represents one of the significant economic problems encountered in aquaculture. These off-flavor compounds are due to the absorption of substances produced by microorganisms. ... -
Determination of Polycyclic Aromatic Hydrocarbons in Sediment by Pressure-Balanced Cold Fiber Solid Phase Microextraction
(American Chemical Society, 2017-09-20)An improved performance of the cold fiber solid phase micro extraction (CF-SPME) technique was accomplished with the use of the pressure balanced procedure. In order to obtain a pressure-balanced state during extraction ... -
Determination of the relationship between vancomycin trough concentrations and the AUC/MIC Dosing
(University of Waterloo, 2020-07-15)Rationale: The recently revised guidelines for the therapeutic monitoring of vancomycin recommend targeting an AUC/MIC of 400-600 for serious methicillin-resistant Staphylococcus aureus (MRSA) infections. The feasibility ... -
Determining Analytical Potential Energy Functions of Diatomic Molecules by Direct Fitting
(University of Waterloo, 2001)The fully quantum mechanical 'direct-potential-fit' (DPF) method has become increasingly widely used in the reduction of diatomic spectra. The central problem of this method is the representation of the potential energy ... -
Determining food web impacts on experimental aquatic systems from the disposal of oil sands process-affected waste materials.
(University of Waterloo, 2006)Current mining operators in the Athabasca oil sands deposit of Alberta, Canada have made commitments to zero discharge of oil sands process-affected waste materials (OSPM) from the mine site and rehabilitation of mined ...