Browsing Science (Faculty of) by Title
Now showing items 699-718 of 3049
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Development of an in vitro eye model to better represent in vivo physiological conditions
(University of Waterloo, 2021-06-23)Purpose The purpose of this thesis was to optimize a novel in vitro blink model, the OcuBlink, to best mimic the physiological characteristics of the human eye. By improving this in vitro model, the results from in vitro ... -
Development of an In Vitro Ocular Platform to Test Contact Lenses
(Journal of Visualized Experiments, 2016-06-04)Currently, in vitro evaluations of contact lenses (CLs) for drug delivery are typically performed in large volume vials,1-6 which fail to mimic physiological tear volumes.7 The traditional model also lacks the natural tear ... -
Development of Cobalt-Doped Nickel Hydroxide Sol-Gel Catalysts for Enhanced Electro-Oxidation of Urea
(University of Waterloo, 2021-05-14)Electrochemical oxidation of urea provides an approach to prevent excess urea emissions into the environment while generating value by capturing chemical energy from waste. Unfortunately, the source of high catalytic ... -
Development of Expression Systems for Various Forms of Human Nitric Oxide Synthase Isozymes
(University of Waterloo, 2015-01-23)Nitric oxide (NO) is one of the important biological molecules which has functions in neurotransmission, vasodilation, and immune responses. However, excess levels of NO have been associated with neurodegenerative and ... -
Development of Field Portable Solid Phase Microextraction Samplers for Performing On-site Environmental Analysis
(University of Waterloo, 2018-04-30)Since being introduced in 1989 solid phase microextraction (SPME) techniques have continually evolved from within the analytical chemistry community due in large part to their clean, portable and easy to handle design. It ... -
Development of Form Visual Acuity in Infants Measured by Schematic Faces
(University of Waterloo, 2018-10-05)Purpose The purpose of this thesis was 1) to develop a test of visual acuity (VA) to measure recognition (form) acuity at a younger age than is currently clinically possible (3 years). Currently, it is only possible to ... -
Development of HPLC-FID Coupling Using Water as the Eluent
(University of Waterloo, 2011-01-24)The characterization of all components of pharmaceutical preparations, especially in the analysis of impurities present at levels higher than 0.05% of the main component, is a challenge in the pharmaceutical industry because ... -
Development of Hydroarylation and Dehydration Methods for Conjugated Polymers
(University of Waterloo, 2017-09-28)Conjugated polymers represent an important next step for solar cell, field effect transistor, and light emitting diode technologies. However, there are several drawbacks to the current syntheses of this class of polymer ... -
Development of III-V Semiconductor Surface Quantum Wells for Hybrid Superconducting Device Applications
(University of Waterloo, 2024-02-20)This thesis concerns the materials development of both InSb/InAlSb and InAs/AlGaSb surface quantum wells: Two of the most promising platforms for the study of proximity-induced superconductivity in semiconductors with ... -
Development of in vitro 3D model systems for screening non-viral neurotrophic factor gene therapies for the retina
(University of Waterloo, 2018-08-21)Glaucoma is a neurodegenerative disease that can lead to a complete loss of vision due to retinal ganglion cell (RGC) death. Therapies that have the capacity to protect and rescue stressed RGCs remain a critical unmet need ... -
Development of Isoelectric Focusing Techniques for Protein Analyses
(University of Waterloo, 2008-10-07)Isoelectric focusing (IEF) is a powerful approach in separations of zwitterionic substances such as proteins, peptides and amino acids. It is important in proteomic research. Generally, in IEF, carrier ampholytes (CAs) are ... -
Development of Models for the Prediction of Short-term and Long-term Toxicity to Hyalella azteca from Separate Exposures to Nickel and Cadmium
(University of Waterloo, 2008-04-30)This study investigated whether principles of the Biotic Ligand Model (BLM), originally developed to predict acute metal toxicity to fish, may be applied to metal accumulation and toxicity in short-term and long-term ... -
Development of Modular Polymeric NPs for Drug Delivery Using Amine-Reactive Chemistry
(University of Waterloo, 2024-01-26)Cancer remains one of the leading causes of death worldwide and very often requires chemotherapy treatment. Despite advances in chemotherapy treatments, some cancers remain difficult to treat due to tumour type, location, ... -
Development of Molybdenum Isotopes as Petroleum Tracers: The Phosphoria Petroleum System, Bighorn Basin, U.S.A.
(University of Waterloo, 2018-05-22)The application of Mo isotope compositions in petroleum systems is a new field of research. In this study, elemental concentrations and Mo isotope compositions were measured on crude oils, asphaltenes separated from the ... -
Development of Needle Trap Devices for Particle Entrapment
(University of Waterloo, 2022-05-25)The importance of studying particle-bound components in aerosol samples has been highlighted during the COVID-19 pandemic, when people tried to stop the spread of droplet-bound viruses by wearing face masks. While the ... -
Development of Needle Trap Technology for On-Site Determinations: Active and Passive Sampling
(American Chemical Society, 2014-05-19)This study presents a thorough evaluation of new prototypes of extended tip needle trap devices (NT), as well as their application to in situ sampling of biological emissions and active/passive on-site sampling of indoor ... -
Development of Needle Trap Technology for On-Site Determinations: Active and Passive Sampling
(ACS, 2014)This study presents a thorough evaluation of new prototypes of extended tip needle trap devices (NT), as well as their application to in situ sampling of biological emissions and active/passive on-site sampling of indoor ... -
Development of New Carbon-Carbon Bond-Forming Strategies: Formation and Reactivity of sp³-gem-Organodimetallic Palladium(II)/MRn Alkane Intermediates (MRn=Dialkylalumino, Trialkylstannyl)
(University of Waterloo, 2006-12-01)Investigation of the catalytic formation, reactivity and synthetic scope of sp³-gem-organodimetallic palladio(II)/main group metal (main group metal = tributylstannyl, dialkylalumino) alkane species has been carried out. ... -
Development of New Domino Reactions of Alkylidene Meldrum’s Acids Involving Friedel-Crafts Chemistry and Catalytic Conjugate Allylation of Alkylidene Meldrum’s Acids
(University of Waterloo, 2009-10-02)Alkylidene Meldrum’s acids are very reactive acceptors in conjugate additions, and are known to be significantly more electrophilic than other α,β-unsaturated carbonyl electrophiles. They also offer advantages in terms of ... -
Development of Novel Molecules as Modulators of Amyloid-β Aggregation
(University of Waterloo, 2021-09-08)Our brain is remarkably special and unique. It has billions of neurons that govern actions and reactions, and enables us to have thoughts, memories, and personality traits – outmost precious assets – that define who we are ...