Science (Faculty of): Recent submissions
Now showing items 1-20 of 3017
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Metabolic engineering strategies for biomanufacturing of chemicals using Yarrowia lipolytica and Escherichia coli
(University of Waterloo, 2024-04-24)This dissertation advances metabolic engineering by optimizing the genetic and metabolic capabilities of Yarrowia lipolytica and Escherichia coli to enhance their applications in biotechnology. It focuses on improving Y. ... -
Evaluation of the Potential Impacts of Submerging the Oxidized Tailings and Adding a Cover Layer at Mine Principale
(University of Waterloo, 2024-04-24)Oxidation of sulfide minerals generates acid and forms various secondary phases including Fe(III) (oxy)hydroxide phases, jarosite, and gypsum, which can attenuate hazardous metal(loid)s by precipitation, co-precipitation, ... -
Chlorophyll-a Mapping in a Large Lake Using Remote Sensing Imagery: A Case Study of Western Lake Ontario
(University of Waterloo, 2024-04-23)Western Lake Ontario (WLO) and Hamilton Harbour (HH) experience significant eutrophication challenges. Despite an overall decrease in the limiting nutrient phosphorus (P) inputs, recurrent nuisance (Cladophora) and ... -
Glacial Dispersion at the Canadian Malartic Gold Deposit
(University of Waterloo, 2024-04-19)A novel drift prospecting approach detected components from previously established bedrock footprints at the world-class Canadian Malartic gold deposit within the site’s surrounding Quaternary sediments. The measured glacial ... -
Correlation Functions of Heavy Operators in AdS/CFT
(University of Waterloo, 2024-04-15)In this thesis we investigate the holographic dual description of correlation functions of heavy operators in conformal field theory. These heavy operators have scaling dimension that scales with the CFT central charge in ... -
Structural and Biochemical Insights into Previously Uncharacterized Activity of Nucleotide-Dependent Phosphoenolpyruvate Carboxykinases
(University of Waterloo, 2024-04-08)Phosphoenolpyruvate carboxykinase (PEPCK) enzymes are central to glucose metabolism, with their main role in catalyzing one of the first steps of gluconeogenesis. In addition to its primary role, PEPCK is also involved, ... -
Evolution of the Laurentide Ice Sheet in north-central Ontario from subglacial sediments
(University of Waterloo, 2024-03-12)Till stratigraphic analysis of 10 sediment bluffs near Ogoki Post in the Hudson and James Bay Lowlands. -
Arylbenzamide and Arylcarboxamide Derivatives as Modulators of Amyloid-Beta Aggregation
(University of Waterloo, 2024-03-11)Alzheimer’s disease (AD) is a complex neurodegenerative disease with increasing incidence and prevalence globally. The current AD therapies based on small molecules offer only symptomatic relief and are not curative ... -
Environmental DNA barcoding as a method of amphibian species detection compared to conventional monitoring techniques in southern Ontario vernal pools
(University of Waterloo, 2024-03-06)Ongoing monitoring is vital for the conservation of amphibian species and is conducted through conventional auditory and visual surveys. A molecular method, termed environmental DNA (eDNA) barcoding, may offer a more ... -
Development and biomedical applications of solid phase micro-extraction (bio-SPME) chemical biopsy devices
(University of Waterloo, 2024-02-22)Micro-sampling is a vital component in modern diagnostics and personalized medicine. In vivo SPME is a novel branch of biomedical applications of SPME (Bio-SPME) that offers unique advantages complementary to existing ... -
Development of III-V Semiconductor Surface Quantum Wells for Hybrid Superconducting Device Applications
(University of Waterloo, 2024-02-20)This thesis concerns the materials development of both InSb/InAlSb and InAs/AlGaSb surface quantum wells: Two of the most promising platforms for the study of proximity-induced superconductivity in semiconductors with ... -
Controlling Exciton Polarization in Transition Metal Doped Indium Oxide Nanocrystals
(University of Waterloo, 2024-02-20)The simultaneous manipulation of electronic charge and spin in dilute magnetic semiconductors (DMSs) doped with transition metal ions has been long considered a holy grail for advancing spintronics and quantum information ... -
Magnetotransport experiments in GaAs 2D holes and RF-QPC readout in a lateral quantum dot device
(University of Waterloo, 2024-02-16)This thesis presents a set of experiments conducted on GaAs/AlGaAs heterostructures fabricated into Hall bars and a lateral quantum dot device. The Hall bar experiments seek to further the understanding of the complexity ... -
Development and Application of a Consumable-Free Modulator for Comprehensive Two-Dimensional Gas Chromatography
(University of Waterloo, 2024-02-16)Comprehensive two-dimensional gas chromatography (GC×GC), is a separation method recognized as offering far greater peak capacity than conventional one-dimensional separations. Today, the most frequently used GC×GC systems ... -
Seasonal and environmental effects on physiological tolerances and gill adaptations of imperilled Eastern Sand Darter (Ammocrypta pellucida)
(University of Waterloo, 2024-02-15)In the absence of accurate biological information, conservation and recovery strategies carry the risk of failing to meet their objectives. Understanding species-specific physiological tolerances is important for several ... -
Proterozoic zircon dates from auriferous zones at the Island Gold deposit: implications for late gold remobilization in the Superior Province
(University of Waterloo, 2024-02-13)The Island Gold deposit is a high-grade Archean orogenic gold deposit within the Michipicoten greenstone belt of the Superior Province. Hosted within the ~2750 Ma felsic to intermediate Wawa metavolcanic assemblage, gold ... -
Transcriptional regulation of North American wood frog (Rana sylvatica) dorsal skin during development and in response to chronic exposure to a microplastics mixture
(University of Waterloo, 2024-02-09)Amphibian populations have been experiencing declines globally for decades due to factors such as habitat loss, invasive species, climate change, overexploitation, pollution, and disease. Skin is an important immune organ ... -
Enhancing the Ministring DNA (msDNA) Purification Using PI-Sce1 Homing Endonuclease/CRISPR-Cas3 Recombinant System
(University of Waterloo, 2024-02-05)In the generation of msDNA the recombinant E. coli cells are transformed by a msDNA generating precursor plasmid, whereupon expression of the Tel protelomerase enzyme, acting on the pal target sequence present in the ... -
Optimization of the Optical Infrastructure and Trapping Potential for a Quantum Processor Based on Trapped Barium Ions
(University of Waterloo, 2024-02-02)Trapped ion quantum computers represent a cutting-edge quantum computing platform, keeping the highest reported state preparation and measurement fidelity of 99.97%. Recently, barium ion has emerged as the research ... -
Thinking outside the box; fast error estimation for next generation galaxy surveys
(University of Waterloo, 2024-01-29)Since the discovery of the accelerated expansion of the universe in the late 90s, the flat $\Lambda$CDM model has reigned as the best explanation for the cosmological phenomena we have observed. In spite of over two decades ...