Browsing Biology by Type "Doctoral Thesis"
Now showing items 1-20 of 167
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Alternative splicing of Lymnaea Cav3 and NALCN ion channel genes serves to alter biophysical properties, membrane expression, and ion selectivity
(University of Waterloo, 2012-08-30)Evidence is presented that Lymnaea contains homologues for mammalian Cav3 and NALCN 4-domain ion channels, which retain key amino acid sequence motifs that differentiate these channels from other 4-domain types. Molecular ... -
Ammonia-oxidizing archaea in engineered biofiltration systems
(University of Waterloo, 2016-12-21)Ammonia is a nitrogenous metabolic waste product that is produced by all animal life. High concentrations of ammonia are toxic to animals and may result in algal blooms and eutrophication in aquatic environments. To prevent ... -
Analysis of heat shock protein 30 gene expression and function in Xenopus laevis A6 kidney epithelial cells
(University of Waterloo, 2014-04-30)Heat shock proteins (HSPs) are molecular chaperones that assist in protein synthesis, folding and degradation and prevent stress-induced protein aggregation. The present study examined the pattern of accumulation of HSP30 ... -
Antimicrobial Peptide Daptomycin and its Inhibition by Pulmonary Surfactant: Biophysical Studies using Model Membrane Systems
(University of Waterloo, 2017-04-25)Daptomycin is a lipopeptide antibiotic that is clinically used to treat severe infections caused by Gram-positive bacteria. It is highly potent against resistant strains of bacteria such as methicillin-resistant Staphylococcus ... -
Application and assessment of multi-wavelength measurements of variable chlorophyll a fluorescence for analysis of irradiance stress, physiological state and community composition in freshwater phytoplankton
(University of Waterloo, 2018-04-24)Phytoplankton are a diverse group of organisms of fundamental importance in aquatic ecosystems. Exposure to high levels of photosynthetically active and ultraviolet radiation (PAR and UVR) is unavoidable for most phytoplankton ... -
Assessing relations among multiple environmental gradients for shallow lakes in Old Crow Flats, Yukon, using hydrological, limnological and community-collaborative research approaches
(University of Waterloo, 2018-01-09)Shallow freshwater ecosystems are undergoing marked hydrological changes associated with a warming Arctic, which causes concern for remote northern communities that access these regions to maintain their traditional ... -
Assessment of hydroecological changes at the Slave River Delta, NWT, using diatoms in seasonal, inter-annual and paleolimnological experiments
(University of Waterloo, 2007-09-27)Relationships between hydrology, limnology and ecology are analyzed in a comprehensive study of water bodies in the Slave River Delta, Northwest Territories, Canada, at a variety of temporal and spatial scales, including ... -
Assessment of toxic cyanobacterial abundance at Hamilton Harbour from analysis of sediment and water
(University of Waterloo, 2014-05-09)The western embayment of Lake Ontario, Hamilton Harbour, is one of the most polluted sites in the Laurentian Great Lakes and in recent years has seen a reoccurrence of cyanobacterial blooms. This study uses a multidisciplinary ... -
Bacterial Chromosome Engineering for Applications in Metabolic Engineering
(University of Waterloo, 2015-10-02)As genetic engineering technologies continue to advance and metabolic engineering projects become more ambitious, the need for chromosome engineering tools is increased. In this thesis, I have described the development of ... -
The behavioural ecology of burbot, Lota lota: Diel migrations, spatial behavioural syndromes, and behavioural thermoregulation in a reservoir resident.
(University of Waterloo, 2015-08-21)While the impacts of hydropower development on diadromous and riverine fish species have received considerable attention, the ecology and behaviour of fish species residing in hydropower reservoirs is not well understood. ... -
Benthic-pelagic coupling and spatial dynamics of nutrient availability for benthic nuisance algae in the rocky nearshore zone of eastern Lake Erie
(University of Waterloo, 2019-09-03)Nuisance Cladophora growth in the nearshore during the summer growing season tends to imply nutrient, particularly phosphorus (P), enrichment in the benthos, especially where there is adequate light and hard substrate that ... -
Beta-parvin Mediates Adhesion Receptor Cross-Talk During Xenopus laevis Gastrulation
(University of Waterloo, 2013-09-27)Modulation of cell adhesion is essential to the cell rearrangements that characterize Xenopus gastrulation. The spatial and temporal regulation of cell movement requires a highly coordinated cross-talk between cadherin and ... -
Bio-optical Modeling of Aquatic Photosynthesis in the Laurentian Great Lakes
(University of Waterloo, 2010-05-19)The methodology of phytoplankton production measurements in the Laurentian Great Lakes and other freshwater lakes has remained largely unchanged in the past 40 years. In most studies photosynthesis from a single water ... -
Bioinformatic insights into the diversity and evolution of bacterial toxins
(University of Waterloo, 2020-01-24)Bacterial toxins are a broad category of molecules ranging from small organic compounds and peptides to large multi-domain or multi-meric enzymes. Several important diseases are caused primarily by bacterial toxins including ... -
Bioinformatic Insights into the Impacts of External Stimuli on the Human Airway
(University of Waterloo, 2021-12-21)The airway epithelium represents a critical component of the human lung that helps orchestrate defences against inhaled substances including air pollution, allergens, bacteria, and viruses. To manage these continuous ... -
Biological responses in rainbow darter (Etheostoma caeruleum) to changes in municipal wastewater quality in the Grand River
(University of Waterloo, 2017-09-27)This thesis is a synthesis of studies that explore the effects of urbanization on a small-bodied fish species, rainbow darter (Etheostoma caeruleum), in the central Grand River (Ontario, Canada) over time. This watershed ... -
Biophysical Studies of Lipid Membranes and their Interactions with Amyloid Peptides
(University of Waterloo, 2015-06-19)Amyloid beta peptides are known to form amyloid fibrils which are implicated in more than 20 currently incurable neurodegenerative diseases, including Alzheimer’s, Huntington’s and Parkinson’s. The proposed mechanism of ... -
Carbon Metabolism and Desiccation Tolerance in the Nitrogen-Fixing Rhizobia Bradyrhizobium japonicum and Sinorhizobium meliloti
(University of Waterloo, 2009-04-22)Most members of the Rhizobiaceae possess single copies of the poly-3-hydroxybutyrate biosynthesis genes, phbA, phbB and phbC. Analysis of the genome sequence of Bradyrhizobium japonicum reveals the presence of five homologues ... -
Cell Cultures from Walleye (Sander vitreus) for Use in Cell Biology and Virology
(University of Waterloo, 2014-09-16)This thesis has developed from the walleye, Sander vitreus (Mitchill), cell lines (WE) and used them to study viral hemorrhagic septicemia virus (VHSV IVb), which is the causative agent for viral hemorrhagic septicaemia ... -
CHARACTERIZATION OF AHR SIGNALING AND THE IMPACT OF POLYCHLORINATED BIPHENYLS ON THE ADAPTIVE RESPONSES TO STRESS IN FISH
(University of Waterloo, 2007-09-13)Persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) are widespread in aquatic systems. These toxicants bioaccumulate in the tissues of aquatic organisms, especially fish as they occupy a position ...