Browsing Chemistry by Author "Reyes-Garcés, Nathaly"
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Biocompatible Solid-Phase Microextraction Nanoelectrospray Ionization: An Unexploited Tool in Bioanalysis
Gómez-Ríos, Germán Augusto; Reyes-Garcés, Nathaly; Bojko, Barbara; Pawliszyn, Janusz (American Chemical Society, 2015-12-09)In recent years, different geometrical configurations of solid-phase microextraction (SPME) have been directly coupled to mass spectrometry, resulting in benefits such as diminishing matrix effects, improvement of detection ... -
The effect of hematocrit on solid-phase microextraction
Reyes-Garcés, Nathaly; Alam, Md. Nazmul; Pawliszyn, Janusz (Elsevier, 2018-02-25)Solid-phase microextraction (SPME) is an approach to sample preparation that has demonstrated its appropriateness for isolating/enriching analytes present in complex biofluids with minimum sample pre-treatment. Several ... -
Evaluation and Application of Microextraction Techniques Coupled with Portable Analytical Instrumentation for On-site Analysis
Reyes-Garcés, Nathaly (University of Waterloo, 2012-12-12)In recent years, on-site analysis has garnered increased interest from the scientific community. The development of smaller, more sophisticated analytical instruments, and the establishment of new environmental regulations ... -
Fast quantitation of opioid isomers in human plasma by differential mobility spectrometry/mass spectrometry via SPME/open-port probe sampling interface
Liu, Chang; Gómez-Ríos, Germán Augusto; Schneider, Bradley B.; Le Blanc, J. C. Yves; Reyes-Garcés, Nathaly; Arnold, Don W.; Covey, Thomas R.; Pawliszyn, Janusz (Elsevier, 2017-10-23)Mass spectrometry (MS) based quantitative approaches typically require a thorough sample clean-up and a decent chromatographic step in order to achieve needed figures of merit. However, in most cases, such processes are ... -
Fast Quantitation of Target Analytes in Small Volumes of Complex Samples by Matrix-Compatible Solid-Phase Microextraction Devices
Piri-Moghadam, Hamed; Ahmadi, Fardin; Reyes-Garcés, Nathaly; Boyaci, Ezel; Reyes-Garces, Nathaly; Aghakhani, Ali; Bojko, Barbara; Pawliszyn, Janusz (Wiley, 2017-06-20)Herein we report the development of solid-phase microextraction (SPME) devices designed to perform fast extraction/enrichment of target analytes present in small volumes of complex matrices (i.e. V <= 10 mu L). Micro-sampling ... -
Open Port Probe Sampling Interface for the Direct Coupling of Biocompatible Solid-Phase Microextraction to Atmospheric Pressure Ionization Mass Spectrometry
Gomez-Rios, German Augusto; Liu, Chang; Tascon, Marcos; Reyes-Garcés, Nathaly; Arnold, Don W.; Covey, Thomas R.; Pawliszyn, Janusz (American Chemical Society, 2017-04-04)In recent years, the direct coupling of solid phase microextraction (SPME) and mass spectrometry (MS) has shown its great potential to improve limits of quantitation, accelerate analysis throughput, and diminish potential ... -
Quantitative analysis of biofluid spots by coated blade spray mass spectrometry, a new approach to rapid screening
Boyaci, Ezel; Gómez-Ríos, Germán Augusto; Pawliszyn, Janusz; Poole, Justen J.; Tascon, Marcos; Reyes-Garcés, Nathaly (Springer Nature, 2017-11-23)This study demonstrates the quantitative capabilities of coated blade spray (CBS) mass spectrometry (MS) for the concomitant analysis of multiple target substances in biofluid spots. In CBS-MS the analytes present in a ... -
Rapid determination of immunosuppressive drug concentrations in whole blood by coated blade spray-tandem mass spectrometry (CBS-MS/MS)
Gómez-Ríos, Germán Augusto; Tascon, Marcos; Reyes-Garcés, Nathaly; Boyaci, Ezel; Poole, Justen J.; Pawliszyn, Janusz (Elsevier, 2018-01-25)Coated Blade Spray (CBS) is a technology that efficiently integrates sample preparation and direct coupling to mass spectrometry (MS) on a single device. In this article, we present CBS-tandem mass spectrometry (CBS-MS/MS) ... -
Solid Phase Microextraction as a Sample Preparation Tool for Targeted and Untargeted Analysis of Biological Matrices
Reyes-Garcés, Nathaly (University of Waterloo, 2017-09-27)Successful determination of small molecules in complex biological systems requires implementation of robust analytical methodologies able to provide reliable information in a cost-effective and efficient manner. Solid phase ... -
Solid Phase Microextraction Devices Prepared on Plastic Support as Potential Single-Use Samplers for Bioanalytical Applications
Reyes-Garcés, Nathaly; Bojko, Barbara; Hein, Dietmar; Pawliszyn, Janusz (American Chemical Society, 2015-09-04)This study presents new thin-film solid phase microextraction (SPME) devices prepared on plastic as potential single-use samplers for bioanalysis. Polybutylene terephthalate (PBT) was selected as a support due to its ...