Browsing Chemistry by Title
Now showing items 413-432 of 842
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Investigation of Crystal Structures and Ultra-Low Thermal Conductivities in Novel Group 14 and 15 Chalcogenides
(University of Waterloo, 2023-12-04)The crystal structures and physical properties of several new group 14 and 15 chalcogenides are discussed in this thesis. The thesis discusses the chalcoantimonates TlLa2Sb3Se9 and La12+zSb9-ySe38-z (simplified as La12Sb9Se38). ... -
Investigation of divalent metal ion detection using 17E DNAzyme Biosensor
(University of Waterloo, 2021-04-30)DNAzymes are in vitro selected oligonucleotides that can catalyze reactions, such as RNA cleavage. Most DNAzymes require metal ions as cofactors. Unlike ribozymes, which have been found in nature, all known DNAzymes are ... -
Investigation of Efficient Synthetic Routes to Conjugated Thiophene-S,S-Dioxide-Based Materials
(University of Waterloo, 2020-10-08)Due to their low cost and desirable properties, many recent efforts in the field of semiconductor research have been devoted to the discovery and investigation of organic materials. Within this field, thiophene-based ... -
An investigation of gas phase ion-molecule complexes involving novel binding modes
(University of Waterloo, 2021-04-16)In this thesis, an innovative method is introduced to advance the study of gas phase clusters and used to analyse a number of novel binding modes. The systematic sampling of cluster surfaces (SSCS) routine, introduced in ... -
Investigation of Immature Cu,Zn Superoxide Dismutase 1 Using Variable Temperature NMR
(University of Waterloo, 2020-09-03)Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results in the death of motor neurons in the spinal cord, cortex, and brain stem. The vast majority of ALS cases arise sporadically, but ... -
The Investigation of Isomers using Differential Mobility Spectrometry and Ultraviolet Photodissociation Spectroscopy
(University of Waterloo, 2022-10-26)The analysis of complex mixtures in mass spectrometry (MS) is often complicated by the presence of isomers exhibiting the same mass-to-charge ratios. Tandem MS can simplify isomer analysis and enable ion characterization ... -
Investigation of Peptides That Exhibit Affinity Towards Advanced Materials
(University of Waterloo, 2017-05-19)A number of commercially employed polymers are refractory to surface modification and may require harsh conditions ranging from corona discharge to halogenation to assemble a functional surface. We are exploring combinatorial ... -
An Investigation of Phosphorous-Based Bioconjugation Techniques for Protein Modification
(University of Waterloo, 2022-04-07)Bioconjugation is a powerful technique allowing for the modification of biomolecules such as proteins. Exposed amino acid residues on the surface of proteins act as chemical handles for the attachment of biomolecules or ... -
INVESTIGATION OF PROTEIN-DRUG INTERACTION USING CAPILLARY ISOELECTRIC FOCUSING WITH WHOLE COLUMN IMAGING DETECTION AND SPECTROSCOPIC TECHNIQUES
(University of Waterloo, 2009-03-26)In this work, the possibilities of understanding protein-drug interactions and the possible modes of action of the drug have been was explored using capillary isoelectric focusing (CIEF) and spectroscopic techniques. The ... -
Investigation of the effect mutations of CaM have upon in vitro and ex vivo function
(University of Waterloo, 2010-01-22)Calmodulin (CaM) is a calcium-binding protein that has promiscuous regulatory interactions with over three hundred intracellular protein targets. The focus of this study was to characterize the functional role of phosphorylated ... -
Investigation of the Electronic Structure and Magnetic Properties of CeO2-X
(University of Waterloo, 2023-09-19)In literature, it has been reported that undoped CeO2 exhibits a room-temperature ferromagnetic-like ordering that does not follow Curie-type behaviour, typically found in magnetic materials. However, none of the proposed ... -
Investigation of the Microbial Glyoxalase System
(University of Waterloo, 2011-05-19)The Glyoxalase system is composed of two metalloenzymes, Glyoxalase I and Glyoxalase II, that catalyze the conversion of toxic, metabolically produced alpha-ketoaldehydes, such as methyglyoxal, in the presence of a thiol ... -
Investigation of the Optical Properties of Nanostructured Transparent Conducting Oxides
(University of Waterloo, 2013-04-30)Transparent conducting oxides (TCOs) usually have high conductivity and transparency in the visible range and have been widely used in daily life. Recently, TCOs have attracted great interest due to their potential ... -
Investigation of the Presence of a G-quadruplex In the Hoechst Dye Binding DNA Aptamer
(University of Waterloo, 2022-04-22)Aptamers are nucleic acid sequences that have been selected to bind to a ligand with high affinity and selectivity. Aptamers have great potential for use in various biotechnological and medical applications but understanding ... -
Investigation of Thermoelectric Thallium Chalcogenides
(University of Waterloo, 2020-01-24)Thermoelectric materials have drawn extensive attention because of their potential to provide assistance in reducing the usage of fossil fuel sources and the greenhouse effect. Throughout this thesis, the purpose was to ... -
Investigations into Intracellular Thiols of Biological Importance
(University of Waterloo, 2007-02-01)The presence of thiols in living systems is critical for the maintenance of cellular redox homeostasis, the maintenance of protein thiol-disulfide ratios and the protection of cells from reactive oxygen species. In addition ... -
Investigations into Streptomyces azureus Thiostrepton-resistance rRNA Methyltransferase and its Cognate Antibiotic
(University of Waterloo, 2008-12-16)Thiostrepton (TS: TS; C72H85N19O18S5) is a thiazoline antibiotic that is effective against Gram-positive bacteria and the malarial parasite, Plasmodium falciparum. Tight binding of TS to the bacterial L11-23S ribosomal RNA ... -
Investigations of Bacterial Methionine Aminopeptidase
(University of Waterloo, 2009-10-05)The pathway representing methionine integration and excision is an increasingly important target in drug design. Methionine aminopeptidase (MetAP), a metalloprotease responsible for cleaving the N-terminal methionine from ... -
Investigations of Magnetic Model Systems Using Coupled Cluster Based Approaches
(University of Waterloo, 2017-08-23)Over the past decades, the quantum mechanical description of magnetic phenomena has been well developed. However, the first principle calculations of the physical properties of magnetic systems is still a challenge. One ... -
Investigations of the Natural Product Antibiotic Thiostrepton from Streptomyces azureus and Associated Mechanisms of Resistance
(University of Waterloo, 2013-03-11)The persistence and propagation of bacterial antibiotic resistance presents significant challenges to the treatment of drug resistant bacteria with current antimicrobial chemotherapies, while a dearth in replacements for ...