Browsing Chemistry by Title
Now showing items 43-62 of 842
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Arborescent Polymers From "Click" Chemistry and Other Methods
(University of Waterloo, 2014-01-02)Graft polymers with a dendritic architecture (arborescent polymers) were synthesized by “click”, anionic, and cationic grafting. Arborescent polystyrene and polybutadiene systems were synthesized by “click” coupling using ... -
Arborescent Polypeptides for Sustained Drug Delivery Applications
(University of Waterloo, 2017-08-09)This Ph.D. dissertation describes the synthesis of arborescent copolymers of generations G1 and G2 designed to serve as drug delivery nanocarriers for cancer treatment. Poly(γ-benzyl L-glutamate) (PBG) building blocks were ... -
Arborescent Polypeptides for the Targeted and Controlled Release of Drugs
(University of Waterloo, 2022-01-20)Amphiphilic block copolymer micelles are commonly used as drug delivery agents, but these micelle structures tend to dissociate upon dilution. In contrast, arborescent copolymers are highly branched unimolecular micelles ... -
Arborescent Polystyrene-graft-Polyisoprene Copolymers as Polymer Processing Additives
(University of Waterloo, 2009-05-01)Some commodity polymers such as linear low density polyethylene (LLDPE) suffer from melt defects including sharkskin, cyclic melt fracture, and gross melt fracture during processing. The occurrence of these defects sets ... -
Aspects of Polymer Chain Dynamics in Solution Studied by Fluorescence
(University of Waterloo, 2008-04-14)Several pyrene-labeled polymers and polypeptides were synthesized and their chain dynamics were characterized using steady-state and time-resolved fluorescence techniques. Firstly, four series of pyrene-labeled polystyrenes ... -
Assembly of DNA-Functionalized Gold Nanoparticles with Gaps and Overhangs in Linker DNA
(American Chemical Society, 2011-04-28)DNA-directed assembly of gold nanoparticles (AuNPs) has been extensively studied because of its important applications in analytical chemistry, materials science, and nanomedicine. In a typical system, two DNA-functionalized ... -
Assembly of DNA-Functionalized Nanoparticles in Alcoholic Solvents Reveals Opposite Thermodynamic and Kinetic Trends for DNA Hybridization
(American Chemical Society, 2010-05-12)DNA has been a key molecule in biotechnology and nanotechnology. To date, the majority of the experiments involving DNA have been performed in aqueous solutions, which may be related to the perception that DNA hybridization ... -
Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry
(American Chemical Society, 2017-02-22)The microsolvated state of a molecule, represented by its interactions with only a small number of solvent molecules, can play a key role in determining the observable bulk properties of the molecule. This is especially ... -
An Assessment of the Spatial and Temporal Variability of Biological Responses to Municipal Wastewater Effluent in Rainbow Darter (Etheostoma caeruleum) Collected along an Urban Gradient
(PLOS, 2016-10-24)Municipal wastewater effluent (MWWE) and its constituents, such as chemicals of emerging concern, pose a potential threat to the sustainability of fish populations by disrupting key endocrine functions in aquatic organisms. ... -
Associations between Oil Additives in Base Oils Probed by Pyrene Excimer Fluorescence
(University of Waterloo, 2017-10-23)A recently developed method based on pyrene excimer fluorescence was used to probe the interactions of important polymeric oil additives. First, three ethylene-propylene (EP) copolymers representative of viscosity index ... -
Asymmetric Alkenylation of Enones and Other α,β-Unsaturated Carbonyl Derivatives Using Chiral 3,3′-Disubstituted Binaphthols and Boronates
(University of Waterloo, 2009-05-22)Various α,β-unsaturated carbonyl compounds and derivatives were explored in order to expand the range of substrates for the 1,4-addition of alkenylboronates using 3,3′-disubstituted binaphthols. Enones 2.60 were examined ... -
Asymmetric Conjugate Addition of Arylboronates to α,β-unsaturated Enones Catalyzed by Substituted Binaphthols
(University of Waterloo, 2009-10-01)Conjugate addition reactions are one of the most widely used carbon-carbon bond forming reactions in organic synthesis. This reaction can form a chiral center and can be used for the synthesis of structurally complex ... -
Asymmetric Conjugate Addition of Boronates to N-Acylimines and β-Silyl-α,β-unsaturated Ketones Catalyzed by 3,3'-Disubstituted Binaphthols
(University of Waterloo, 2009-01-23)In order to extend the scope of asymmetric conjugate alkenylation catalyzed by 3,3′-disubstituted binaphthols, two classes of compounds were examined. Asymmetric 1,4-addition of alkenylboronates onto N-acylimines was ... -
Asymmetric Conjugate Additions of Boronates to α,β-Unsaturated Trifluoromethyl Ketones and Strategies Towards Asymmetric Conjugate Additions of N-Boc-Pyrrole Boronic Acid
(University of Waterloo, 2016-08-24)An important class of organic molecules are those that contain fluorine. Fluorinated molecules have found widespread use in medicinal chemistry, as well as in agrochemicals. This is due to the ability of fluorine to act ... -
Asymmetric soft-hard colloidal mixtures: osmotic effects, glassy states and rheology
(American Institute of Physics, 2017-09-06)Whereas mixtures of colloids and non-adsorbing polymers have been studied in great detail in the last two decades, binary colloidal mixtures have not received much attention. Yet, fragmental evidence from asymmetric mixtures ... -
Asymmetric Synthesis using 3,3'-Disubstituted Binaphthol-modified Boronates
(University of Waterloo, 2006)A number of 3,3'-disubstituted binaphthol-modified allylboronates (<strong>2. 42a-m</strong>) were prepared from the reaction between triallylborane and the corresponding 3,3'-disubstituted binaphthols. These chiral ... -
Attaching DNA to Nanoceria: Regulating Oxidase Activity and Fluorescence Quenching
(American Chemical Society, 2013-08-14)Cerium oxide nanoparticles (nanoceria) have recently emerged as a nanozyme with oxidase activity. In this work, we present a few important interfacial properties of nanoceria. First, the surface charge of nanoceria can be ... -
Augmenting Basin-Hopping With Techniques From Unsupervised Machine Learning: Applications in Spectroscopy and Ion Mobility
(Frontiers, 2019-08-07)Evolutionary algorithms such as the basin-hopping (BH) algorithm have proven to be useful for difficult non-linear optimization problems with multiple modalities and variables. Applications of these algorithms range from ... -
Automated High-throughput Analysis of Multi-class Multi-residue Pharmaceutical Drugs in Animal Tissue Using Solid Phase Microextraction
(University of Waterloo, 2020-05-06)The use of veterinary pharmaceuticals in today´s intensive farming of food-producing animals is essential for the humane treatment of animals and as well as for the prevention of outbreaks of infectious diseases. Improper ... -
The automatic use of capillary isoelectric focusing with whole column imaging detection for carbamazepine binding to human serum albumin
(Elsevier, 2017-08-05)The binding of the anticonvulsant drug carbamazepine (CBZ) to human serum albumin, both without (dHSA) and in the presence of fatty acids (HSA) was studied in real time by capillary isoelectric focusing with whole column ...