Pharmacy
This is the collection for the University of Waterloo's School of Pharmacy , which includes papers submitted at the conclusion of pharmacy residencies administrated by the School of Pharmacy.
Research outputs are organized by type (eg. Master Thesis, Article, Conference Paper).
Waterloo faculty, students, and staff can contact us or visit the UWSpace guide to learn more about depositing their research.
Recent deposits
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Arylbenzamide and Arylcarboxamide Derivatives as Modulators of Amyloid-Beta Aggregation
(University of Waterloo, 2024-03-11)Alzheimer’s disease (AD) is a complex neurodegenerative disease with increasing incidence and prevalence globally. The current AD therapies based on small molecules offer only symptomatic relief and are not curative ... -
Enhancing the Ministring DNA (msDNA) Purification Using PI-Sce1 Homing Endonuclease/CRISPR-Cas3 Recombinant System
(University of Waterloo, 2024-02-05)In the generation of msDNA the recombinant E. coli cells are transformed by a msDNA generating precursor plasmid, whereupon expression of the Tel protelomerase enzyme, acting on the pal target sequence present in the ... -
Development of Modular Polymeric NPs for Drug Delivery Using Amine-Reactive Chemistry
(University of Waterloo, 2024-01-26)Cancer remains one of the leading causes of death worldwide and very often requires chemotherapy treatment. Despite advances in chemotherapy treatments, some cancers remain difficult to treat due to tumour type, location, ... -
Probing the interactions that drive RNA binding and self-association of hnRNPA1 implicated in neurodegeneration
(University of Waterloo, 2024-01-17)The heteronuclear ribonucleoprotein A1 (hnRNPA1 or A1) is associated with the pathology of different diseases, including neurological disorders and cancers. In particular, the aggregation and dysfunction of A1 has been ... -
Medication Review in Cognitive Impairment and Dementia: Comparison of Instruments
(University of Waterloo, 2023-12-19)Background: - Cognitive impairment (CI) and dementia are significant concerns in older adults in Canada. Drug-related problems (DRPs) are common and can cause up to 30% of hospitalizations in older individuals, including ... -
Serious Games on the Lived Experience of Dementia as Learning Tools in Pharmacy Education
(University of Waterloo, 2023-10-23)Dementia is a stigmatized and often ‘invisible’ condition which requires clinicians to have a nuanced understanding of the lived experience to build trust and provide better quality of care. Pharmacists are at the frontline ... -
Machine learning modelling in predicting and optimizing PLGA nanoparticle encapsulation efficiency and therapeutic efficacy
(University of Waterloo, 2023-09-20)Nanoparticles (NP) have become a promising drug delivery system in the past few decades in pharmaceutics for its diversity in encapsulating different types of drugs, including proteins/peptides, nucleic acids and small ... -
Evaluation of feasibility and potential impact of a clinical innovative software tool to support pharmacists to prescribe for minor ailments
(University of Waterloo, 2023-09-05)Background: The role of community pharmacists has shifted from dispensing prescribed medications to providing patient-focused clinical services such as Pharmacists Prescribing for Minor Ailments (PPMA). These services are ... -
Design and Characterization of Various Lipid, Polymer, and Gemini-Surfactant – Based Vectors and DNA as Non-Viral Delivery Systems for Gene Therapy Applications
(University of Waterloo, 2023-08-31)The bulk of this thesis work is the result of a pharmaceutical collaboration, and it utilizes several proprietary systems. While Chapters 3 and 4 will provide an in-depth discussion of the results, the specific names, ... -
Piperine Derivatives as Modulators of Amyloid-Beta (Aβ) Aggregation
(University of Waterloo, 2023-07-12)Alzheimer’s Disease (AD) is a life-changing neurodegenerative disease that progresses in stages and currently has no effective cure. More than 597,000 Canadians suffer from AD. Symptoms of late-stage AD are severe and ... -
Investigating the Interactions of Fatty Acids, Amyloid Beta & SARS-CoV-2 Spike Protein Fragment
(University of Waterloo, 2023-05-16)There is no cure for Alzheimer’s disease (AD), and the negative implications of having AD were further exacerbated in recent years, as patients with dementia are at the highest risk for mortality upon contracting COVID-19. ... -
Pediatric Physiologically Based Pharmacokinetic (PBPK) Modeling to Advance Knowledge of Breastfeeding Infant Exposure to Maternal Medications
(University of Waterloo, 2023-05-04)While there are benefits of breastfeeding to the maternal-infant pair, mothers taking medication may decide not to breastfeed amid unclear risks of exposing the infant to the drug through milk. Uncertainty arises mainly ... -
The associations between insulin, hypoglycemia, and dementia: Combating threats to internal validity in a series of population-based cohort studies
(University of Waterloo, 2023-05-01)Although the association between type 2 diabetes and dementia is recognized, findings from the epidemiology literature on the effect of insulin and one of its side effects, hypoglycemia, are less clear. The currently ... -
Pharmacokinetic and economic implications when switching between hemophilia A treatments
(University of Waterloo, 2023-04-18)Hemophilia is a bleeding disorder in which the blood is unable to form clots, and is also classified as severe (defined as having an endogenous factor VIII [FVIII] concentration < 1 IU/dL, or 1%), moderate (1-5%) or mild ... -
In-solution and physical state properties of polymer and lipid excipients and their effects on the supersaturation evolution of poorly water-soluble drugs
(University of Waterloo, 2023-04-14)Solubility has become an increasing issue for the pharmaceutical industry, as the advances in combinatorial chemistry and high throughput screening methods have resulted in an increase in the molecular weight and lipophilicity ... -
Clinical Pharmacy Services in Ambulatory Oncology: An Environmental Scan of the Canadian Practice Landscape
(University of Waterloo, 2023-02-21)Background: Canadian clinical pharmacy key performance indicators (cpKPIs) have been developed for inpatient hospital practice but are not established for ambulatory oncology. This study represents the first step in ... -
Evaluation of a microlearning module on hypertension in Canada
(University of Waterloo, 2023-02-20)Objectives: To use a microlearning platform to evaluate pharmacists’ knowledge and behaviour related to hypertension. Methods: Pharmacy 5in5 is an online microlearning platform designed to help pharmacy professionals ... -
The Interplay Between the Neuronal Plasma Membrane and Cell Signaling in Alzheimer’s Disease
(University of Waterloo, 2023-03-10)The lack of understanding in the molecular and cellular mechanisms of Alzheimer’s disease (AD) has hindered efforts towards finding treatments that effectively modify disease trajectory. Therapeutic development for AD has ... -
Development of a Framework for Identifying Critical Input Parameters for Effective Pediatric PBPK/PBTK Modelling
(University of Waterloo, 2023-01-20)Within a physiologically based pharmacokinetic (PBPK) model framework, virtual children are built based on known trajectories of anatomy and physiology across age and a compounds transfer within the body is defined by ... -
The construction and characterization of a synthetic SARS VLP comprised of betacoronavirus consensus sequence-encoded viral components
(University of Waterloo, 2022-12-22)In 2019, a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged from Wuhan, China leading to the COVID-19 pandemic. Although there was an outbreak of severe acute respiratory syndrome ...