Browsing Kinesiology and Health Sciences by Type "Doctoral Thesis"
Now showing items 1-20 of 127
-
Acute Regulation of Vascular Tone by AMP-activated Protein Kinase in Arteries of Healthy, Hypertensive and Aged Rats
(University of Waterloo, 2011-12-21)Background, Rationale and General Purpose: Several seminal observations suggest that AMPK mediates vascular tone: 1) in endothelial cell culture and in vitro isolated protein experiments, activation of AMPK stimulates ... -
Age-related changes in the control of mediolateral dynamic stability during volitional and reactive stepping
(University of Waterloo, 2012-04-23)The high incidence of falls and fall-related injuries among Canadians over the age of 65 continues to be a key public health issue. As the current proportion of individuals within this cohort of the population is predicted ... -
The aging spine: The effect of cyclic loading, simulated degeneration and prolonged sitting on joint stiffness across age
(University of Waterloo, 2018-08-22)Background: Low back pain is estimated to have a lifetime prevalence as high as 84%, and both the severity and frequency of low back pain reporting have a dependency on age. The nucleus pulposus and annulus fibrosis of ... -
Analysis of Transcranial Doppler Ultrasound Waveform Morphology for the Assessment of Cerebrovascular Hemodynamics
(University of Waterloo, 2012-08-29)The use of transcranial Doppler (TCD) ultrasound for the assessment of cerebral blood flow velocity (CBFV) provides an indication of cerebral blood flow assuming the diameter of the insonated vessel remains constant. Studies ... -
Anticipatory planning in object manipulation: A cross-sectional investigation of children, young adults and older adults
(University of Waterloo, 2016-08-25)Over a series of five studies, this work aimed to investigate anticipatory planning in object manipulation across the human lifespan. Main objectives were to: (a) understand the influence of the movement context; (b) ... -
Aperture Crossing in Challenging Environments: An Examination of the Factors that Influence the Passability of Narrow Spaces
(University of Waterloo, 2016-04-13)In order to get to where we need to go, locomotion often involves walking through narrow spaces. Whether an aperture affords passage is thought to be determined by the body size/aperture size relationship. For normal, ... -
Axial twist loading of the spine: Modulators of injury mechanisms and the potential for pain generation.
(University of Waterloo, 2008-05-26)There are several reasons to research the effects of axial twist exposures and the resulting loading on the spine. The lack of consensus from the limited work that has previously examined the role of axial twist moments ... -
Axial twist of the lumbar spine: Mechanical responses to twisted postures and potential factors for workplace injury
(University of Waterloo, 2017-08-24)While a link between magnitudes of spinal axial twist motions and the various modes of associated injury, pain reporting, and lost time claims has been tentatively established, there is need for greater investigation and ... -
A biomechanical investigation into the link between simulated job static strength and psychophysical strength: Do they share a “weakest link” relationship?
(University of Waterloo, 2011-01-17)Maximum voluntary forces and psychophysically acceptable forces are often used to set force guidelines for exertions as a means to protect against overexertion injuries in the workplace. The focus of this dissertation was ... -
Biomechanical Predictors of Functionally Induced Low Back Pain, Acute Response to Prolonged Standing Exposure, and Impact of a Stabilization-Based Clinical Exercise Intervention
(University of Waterloo, 2009-07-24)Purpose: Biomechanical differences between people with low back pain (LBP) and healthy controls have been shown previously. LBP has been associated with standing postures in occupational settings. A transient pain-generating ... -
A Biomechanical-Biochemical Hypothesis for the Role of Collagen in Injury
(University of Waterloo, 2022-07-25)Low back pain affects 80% of the population at some point in their lives and is the most common musculoskeletal complaint for workplace injuries. Further, it presents as episodic, with sufferers typically experiencing ... -
Breast cancer survivor functional changes immediately following treatment: quantifying mechanisms of strength deficits and compensatory kinematic and muscular strategy adaptations
(University of Waterloo, 2021-11-04)Breast cancer is prevalent among Canadian women, but treatments may cause functional impairments among survivors. Over 22,000 Canadian women join the survivor population yearly (Brenner et al., 2020). Despite this substantial ... -
Bridging the gap between physical activity evidence and practice for older adults with osteoporosis and frailty
(University of Waterloo, 2021-12-09)Exercise prescriptions that include moderate or high intensity progressive, resistance training, and functional and balance training may improve physical functioning and disability outcomes and prevent falls in older adults ... -
Cardiovascular responses of women to orthostatic stress, the effects of the menstrual cycle and age, and a comparison to men
(University of Waterloo, 2010-08-10)Young women are known to exhibit a greater incidence of orthostatic hypotension than men. The exact mechanisms for this are unclear and it has been proposed to be related to cardiac filling, peripheral resistance, and/or ... -
Cerebrovascular hemodynamics in older adults: Associations with lifestyle, peripheral vascular health and functional decline
(University of Waterloo, 2013-04-25)In today’s aging population, cerebrovascular health plays a pivotal role in maintaining independence. The identification of early markers of change might help to plan more appropriate preventative and/or therapeutic measures. ... -
Cerebrovascular Hemodynamics, Postural Stability, Gait Dynamics, and Falls in Older Adults
(University of Waterloo, 2018-04-26)Injurious falls in community-living older adults are associated with standing up suggesting that cerebral hypoperfusion following a postural transition might be a contributing factor. A large population study has recently ... -
Characterization of the effect of the menstrual cycle, estradiol and Fads2 transcript variants on fatty acid composition and enzyme expression
(University of Waterloo, 2016-08-29)Estrogen is believed to regulate fatty acid composition based on observations of differences between men and women, and changes associated with altered estrogen levels in women during pregnancy, menopause and hormone ... -
Characterization of the effects of sex, pregnancy, and 17β-estradiol on docosahexaenoic acid biosynthesis
(University of Waterloo, 2013-09-27)Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid (n-3 PUFA) required for fetal neurodevelopment. Increased DHA levels are associated with 17β-estradiol levels, as DHA is higher in women relative to men ... -
Characterizing a Novel Enzyme Involved in Cardiolipin Remodelling
(University of Waterloo, 2023-12-05)Background: Cardiolipin (CL) is a specialized dimeric phospholipid comprising approximately 25% of total phospholipids in the inner mitochondrial membrane in eukaryotes, where it functions in energy metabolism, autophagy ... -
Characterizing site-specific body composition of older adults and their associations with strength, functional capacity, and metabolic health
(University of Waterloo, 2021-06-03)Background: Ageing is associated with skeletal muscle atrophy and increased intramuscular adipose tissue. Emerging evidence indicates that specific muscle groups may be largely responsible for the ageing-related degradation ...