Browsing Science (Faculty of) by Title
Now showing items 679-698 of 3049
-
Development of a Carbon Mesh Supported Thin Film Microextraction Membrane As a Means to Lower the Detection Limits of Benchtop and Portable GC/MS Instrumentation
(American Chemical Society, 2015-12-18)In this work, a durable and easy to handle thin film microextraction (TFME) device is reported. The membrane is comprised of poly(divinylbenzene) (DVB) resin particles suspended in a high-density polydimethylsiloxane (PDMS) ... -
Development of a correlation based and a decision tree based prediction algorithm for tissue to plasma partition coefficients
(University of Waterloo, 2013-04-29)Physiologically based pharmacokinetic (PBPK) modeling is a tool used in drug discovery and human health risk assessment. PBPK models are mathematical representations of the anatomy, physiology and biochemistry of an organism. ... -
Development of a Cost-Effective and Consumable-Free Interface for Comprehensive Two-Dimensional Gas Chromatography (GC×GC)
(University of Waterloo, 2007-05-23)The biggest limitation to conventional gas chromatography (GC) is limited peak capacity, making the analysis of complex mixtures a difficult or even impossible task. Comprehensive two-dimensional gas chromatography (GC×GC) ... -
Development of a Framework for Identifying Critical Input Parameters for Effective Pediatric PBPK/PBTK Modelling
(University of Waterloo, 2023-01-20)Within a physiologically based pharmacokinetic (PBPK) model framework, virtual children are built based on known trajectories of anatomy and physiology across age and a compounds transfer within the body is defined by ... -
Development of a Hybrid Hydrogel Bio-ink for 3D Printing of Biomimetic Tissue Constructs
(University of Waterloo, 2019-05-24)Colorectal cancer is the 2nd most common form of cancer in Canada. Most colorectal cancer deaths are caused by complications that stem from the metastasis of colorectal cancer to other organs such as the liver. During ... -
Development of a Microfluidic Hemodialysis Device Equipped with an Antifouling Nanoporous Dialysis Membrane
(University of Waterloo, 2021-06-08)This thesis presents a microfluidic hemodialyzer and an experimental platform and demonstrates that the performance of a polycarbonate membrane used in a continuous setting that can be comparable to commercial hollow-fibre ... -
Development of a multichannel microfluidic system with Schlieren imaging microscopy for online chip-based moving boundary electrophoresis
(Elsevier, 2017-02-10)The concentration gradient detection method based on the Schlieren optics employed for electrophoresis analyses by extending the technology to a multi-channel system using a prototyped microfluidic chip (thinXXS Micro-technology, ... -
Development of a new grading scale for tear ferning
(Elsevier, 2013-10-25)Purpose: This paper reports on the development of a new tear ferning (TF) subjective grading scale, and compares it with the Rolando scale. Method: TF patterns obtained from tear film samples collected from normal and dry ... -
Development of a New Technique to Study the Kinetics of Hydroxyl Radical Uptake on Micron-Sized Organic Aerosols
(University of Waterloo, 2010-04-28)The importance of the hydroxyl radical (OH) to tropospheric chemistry is well known. The radicals’ ability to react with most atmospheric trace gases allows it to act as the main removal mechanism for these gases. Due to ... -
Development of a Novel, Microemulsion System for the Simultaneous Delivery of Hydrophilic and Hydrophobic Active Pharmaceutical Ingredients (APIs)
(University of Waterloo, 2020-09-28)Concurrent chronic disease and ensuing multi-morbidity are a debilitating reality for millions of Canadians. This adversity is compounded by increased pill burden and decreased patient adherence. Microemulsions (MEs) serve ... -
Development of a Parallel Computational Framework to Solve Flow and Transport in Integrated Surface-Subsurface Hydrologic Systems
(University of Waterloo, 2012-04-11)HydroGeoSphere (HGS) is a 3D control-volume finite element hydrologic model describing fully-integrated surface-subsurface water flow and solute and thermal energy transport. Because the model solves tightly-coupled ... -
Development of a Single-Stage Modulator for Comprehensive Two-Dimensional Gas Chromatography (GC × GC)
(University of Waterloo, 2011-02-22)The ability to effectively analyze particulate matter (PM2.5) in air is becoming increasingly pertinent. Allen Goldstein of the University of California in Berkeley is studying the semi-volatile fraction of organic compounds ... -
Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo): Study Protocol
(JMIR Publications, 2016-12-15)Background: Individual pharmacokinetic assessment is a critical component of tailored prophylaxis for hemophilia patients. Population pharmacokinetics allows using individual sparse data, thus simplifying individual ... -
Development of Advanced Polymer-Soil Composites as High-Performance Construction Materials
(University of Waterloo, 2023-01-23)Construction using earth materials is an old building practice that can be traced back to approximately 10,000 BC. Costs for this type of construction are low because local materials are utilized, and structures are built ... -
The Development of an Average, Anatomically Based, Young Adult, GRIN Eye Model
(University of Waterloo, 2005)The purpose of this thesis is to describe the development of an anatomically based, young adult eye model, which includes a crystalline lens with a gradient refractive index (GRIN). This model will then be used to ... -
The Development of an Antibody-Drug Conjugate to Specifically Target and Soften the Crystalline Lens in vivo
(University of Waterloo, 2017-04-04)Helmholtz’s classical theory of accommodation states that, within the eye, contraction of the annular ciliary muscle releases the passive tension of zonules that hold the lens in a flattened state. As a result, the surface ... -
Development of an Arabic Continuous Text Near Acuity Chart
(University of Waterloo, 2017-04-24)Purpose: Near visual acuity is an essential measurement during an oculo-visual assessment. Continuous text near visual acuity charts measure reading acuity and other aspects of reading performance. Arabic is ranked as the ... -
Development of an Assay System for the Determination of Transketolase and Transaldolase Activities in Hyperthermophilic Bacteria and Archaea
(University of Waterloo, 2012-03-01)Only a few hyperthermophilic archaea are found to have a complete nonoxidative stage of pentose phosphate pathway (NOPPP), which indicates that most archaeal hyperthermophiles are partially missing pentose metabolizing ... -
Development of an Automatic Code Generator and Implementation of Multireference Equation of Motion Coupled-Cluster Theory in the ORCA Program Package
(University of Waterloo, 2015-10-01)Over the past 50 years, single-reference coupled-cluster theory has emerged as a cornerstone of quantum chemistry. While it is an accurate methodology for the calculation of the properties of the electronic states of many ... -
Development of an endothelial-like cell line from the brain of the American eel and its use to study the effects of selenium
(University of Waterloo, 2017-02-14)A cell line, eelB, has been developed in this thesis from the brain of the American eel, Anguilla rostrata (Lesueur), an endangered species and belonging to a group of fish that for unknown reasons appear to be in worldwide ...