Browsing Pharmacy by Author "McEneny-King, Alanna"
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Data Analysis Protocol for the Development and Evaluation of Population Pharmacokinetic Models for Incorporation Into the Web-Accessible Population Pharmacokinetic Service - Hemophilia (WAPPS-Hemo)
McEneny-King, Alanna; Foster, Gary; Iorio, Alfonso; Edginton, Andrea N. (JMIR Publications, 2016-12-07)Background: Hemophilia is an inherited bleeding disorder caused by a deficiency in a specific clotting factor. This results in spontaneous bleeding episodes and eventual arthropathy. The mainstay of hemophilia treatment ... -
Development of a Web-Accessible Population Pharmacokinetic Service-Hemophilia (WAPPS-Hemo): Study Protocol
Iorio, Alfonso; Keepanasseril, Arun; Foster, Gary; Navarro-Ruan, Tamara; McEneny-King, Alanna; Edginton, Andrea N.; Thabane, Lehana (JMIR Publications, 2016-12-15)Background: Individual pharmacokinetic assessment is a critical component of tailored prophylaxis for hemophilia patients. Population pharmacokinetics allows using individual sparse data, thus simplifying individual ... -
Metabolism, transport, and physiologically based pharmacokinetic modelling of novel tacrine derivatives
McEneny-King, Alanna (University of Waterloo, 2015-08-26)Alzheimer’s disease (AD) is the most prevalent form of dementia affecting the elderly population, and its burden is rapidly growing both in Canada and worldwide. As a result, there is a substantial need for more effective ... -
Modeling of Body Weight Metrics for Effective and Cost-Efficient Conventional Factor VIII Dosing in Hemophilia A Prophylaxis
McEneny-King, Alanna; Chelle, Pierre; Henrard, Severine; Hermans, Cedric; Iorio, Alfonso; Edginton, Andrea N. (MDPI, 2017-12-01)The total body weight-based dosing strategy currently used in the prophylactic treatment of hemophilia A may not be appropriate for all populations. The assumptions that guide weight-based dosing are not valid in overweight ... -
Pharmacokinetic modelling of clinically relevant situations in the treatment of hemophilia A and B
McEneny-King, Alanna (University of Waterloo, 2020-04-03)Hemophilia is a congenital bleeding disorder caused by deficiency of clotting factor VIII (FVIII; hemophilia A) or IX (FIX; hemophilia B). Severe hemophilia patients have less than 1% (or 1 IU/dL) of normal factor activity, ...