Browsing Pharmacy by Subject "Gemini surfactants"
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Characterization of counterion effects of gemini surfactants and in vitro studies of transfection efficiency for gene therapy in epithelial ovarian cancer.
(University of Waterloo, 2015-01-23)Gene therapy has emerged as a promising strategy for the treatment or prevention of many acquired or genetic diseases that are considered incurable at the present time. Although viral and non-viral vector approaches are ... -
Design and Characterization of Various Lipid, Polymer, and Gemini-Surfactant – Based Vectors and DNA as Non-Viral Delivery Systems for Gene Therapy Applications
(University of Waterloo, 2023-08-31)The bulk of this thesis work is the result of a pharmaceutical collaboration, and it utilizes several proprietary systems. While Chapters 3 and 4 will provide an in-depth discussion of the results, the specific names, ... -
Optimized Production and Purification of LCC DNA Minivectors for Applications in Gene Therapy and Vaccine Development
(University of Waterloo, 2014-01-28)Linear covalently closed (LCC) DNA minivectors serve to be superior to conventional circular covalently closed (CCC) plasmid DNA (pDNA) vectors due to enhancements to both transfection efficiency and safety. Specifically, ...