Browsing Biology by Title
Now showing items 415-434 of 597
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Nanoscale Characterization of Melatonin and Amyloid Beta in Model Membranes- in Relation to Alzheimer's Disease
(University of Waterloo, 2014-12-03)Increasing evidence suggests that cell membranes play an important role in the pathophysiology of Alzheimer's disease (AD). Direct interaction of small molecules, such as cholesterol and melatonin, with cellular membrane ... -
Native Wetland Plant Recovery Following Phragmites australis Invasion
(University of Waterloo, 2022-05-20)Invasive common reed (Phragmites australis ssp. australis) has negatively affected 25% of all Species at Risk in Ontario since its arrival in the twentieth century. This is of particular concern at Long Point and Rondeau, ... -
Near real-time determination of B.1.1.7 in proportion to total SARS-CoV-2 viral load in wastewater using an allele-specific primer extension PCR strategy
(Elsevier, 2021-10-15)"The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome corona- virus 2 (SARS-CoV-2) has claimed millions of lives to date. Antigenic drift has resulted in viral variants ... -
Network centrality analysis of eye-gaze data in autism spectrum disorder
(Elsevier, 2019-08)Individuals suffering from autism spectrum disorder (ASD) exhibit impaired social communication, the manifestations of which include abnormal eye contact and gaze. In this study, we first seek to characterize the spatial ... -
Neural Tube Defect-causing Teratogens Affect Tissue Mechanical Properties and Cytoskeletal Morphology in Axolotl Embryos
(University of Waterloo, 2007-11-22)The teratogenic drugs cytochalasin B and valproic acid have been shown to alter F-actin polymerization, an effect that is crucial in forming microfilaments. Microfilaments form important cytoskeletal structures that maintain ... -
Neuregulin’s role in regulating the anti-inflammatory pathway
(University of Waterloo, 2009-08-12)Inflammation can be up-regulated by microglia and macrophages through the release of pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-α). Excess production of TNF-α can lead to a variety of diseases and ... -
A new angle on plastic debris in the aquatic environment: Investigating interactions between viral hemorrhagic septicemia virus (VHSV) and inanimate surfaces
(University of Waterloo, 2009-08-28)Methods of studying the interaction between fish viruses with inanimate surfaces were developed and used to explore several variables. Viral hemorrhagic septicemia virus (VHSV) was used as the model virus. The EPC cell ... -
Non-specific immune response and disease-resistance in Chinook salmon (Oncorhynchus tshawytscha) supplemented with probiotics
(University of Waterloo, 2023-09-21)Finfish aquaculture is the fastest-growing food-production sector in the world. Nevertheless, intensive production faces increased disease outbreaks due to high stock densities and environmental effects. Currently, infectious ... -
Nutrient sources for excessive growth of benthic algae in Lake Ontario as inferred by the distribution of SRP
(University of Waterloo, 2010-11-30)Total phosphorus concentrations in the open waters of the Laurentian Great Lakes are currently at or beneath target concentrations set by international agreement. Despite the success of phosphorus loading controls in ... -
An Obese Genotype Affects Apoptosis Related Gene Expression
(University of Waterloo, 2009-01-15)Apoptosis is a genetically regulated form of cell death that occurs when the cell is exposed to physiological, pathogenic, or cytotoxic stimuli. Unregulated apoptosis (too much or too little apoptosis) at any time from ... -
An Obese Genotype Affects the Sphingolipid Signaling Pathway
(University of Waterloo, 2008-01-24)Sphingolipids are important signaling molecules regulating cell growth, cell death and differentiation, thus making them important molecules in determining the fate of a cell and in the pathogenesis of chronic illnesses. ... -
Obesity associated colon tumorigenesis: An assessment of tumor phenotype
(University of Waterloo, 2006)Colon cancer and obesity are two significant and related pathological states with multiple etiological factors. In this dissertation, it was hypothesized that tumor growth is accelerated in the altered state of obesity ... -
Occurrence and Seasonal Variability of Selected Pharmaceuticals in Southern Ontario Drinking Water Supplies
(University of Waterloo, 2007-04-27)The presence and seasonal variability of human and veterinary pharmaceuticals in surface water (raw water) and treated water samples from two drinking water facilities in Southern Ontario was investigated. Water samples ... -
Occurrence, Fate, and Mobility of Antibiotic Resistant Bacteria and Antibiotic Resistance Genes among Microbial Communities Exposed to Alternative Wastewater Treatment Systems
(University of Waterloo, 2012-08-29)The ubiquitous nature of antibiotic resistance and antibiotic resistance genes (ARGs) among environmental pathogens from a variety of wastewater effluents, suggests that the aquatic environment, and specifically alternative ... -
OEP15-1 and OEP7.3 Localize to the Outer Envelope of Chloroplasts Using a Novel and Uncharacterized Targeting Pathway
(University of Waterloo, 2021-09-27)Chloroplasts originated from an endosymbiotic event where a Gram-negative cyanobacterium was engulfed by an ancestral eukaryotic cell. The genome of the endosymbiont has since gone through extensive gene transfer to the ... -
Onion Root Anatomy and the Uptake of Sulphate and Phosphate Ions
(University of Waterloo, 2007-06-12)Ions in the soil solution traverse many layers (epidermis, exodermis, central cortex, and endodermis) within the root to reach the stele. The endodermis is present in almost all vascular plants while the exodermis is found ... -
Optimal sampling methods for modelling the occupancy of Arctic grayling (Thymallus arcticus) in the Canadian Barrenlands
(Canadian Science Publishing, 2017)In occupancy models, imperfect detectability of animals is usually corrected for by using temporally-repeated surveys to estimate probability of detection. Substituting spatial replicates for temporal replicates could be ... -
Optimizing protein S-acylation detection in autophagy
(University of Waterloo, 2021-06-04)S-acylation, sometimes referred to as S-palmitoylation or simply palmitoylation, is a posttranslational protein modification involving the covalent addition of a fatty acid to cysteine residues. Since the first characterization ... -
Organic Tissue Stoichiometry of Cladophora glomerata and its Relation to Coastal Land Use in the Laurentian Great Lakes
(University of Waterloo, 2008-01-04)The relationships between C:N:P (carbon, nitrogen, and phosphorus) stoichiometry of Cladophora glomerata and land use characteristics in selected nearshore areas of the lower Laurentian Great Lakes were determined during ... -
The origin, transformation and deposition of sediments in Lake Bosomtwe/Bosumtwi (Ghana, West Africa)
(University of Waterloo, 2010-05-21)Recent drought over West Africa (1970s-present) has been a global concern, and the ability to predict the frequency and severity of future droughts is important to mitigate the devastating socio-economic effects of drought. ...