Browsing Biology by Title
Now showing items 546-565 of 597
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Tapasin's protein interactions in the rainbow trout peptide-loading complex
(Elsevier, 2018-04-01)Major histocompatibility complex (MHC) class I receptors play a key role in the immune system by presenting non-self peptides to T cell lymphocytes. In humans, the assembly of the MHC class I with a peptide is mediated by ... -
Targeted enrichment of cellulase genes using stable-isotope probing and metagenomics
(University of Waterloo, 2012-01-23)Cellulose is the most abundant organic compound on the planet, and is found in nearly every ecosystem. Cellulose is also the most abundant waste product produced by human activity. These enormous stores of natural cellulose ... -
Targeting novel soil glycosyl hydrolases by combining stable isotope probing and metagenomics
(University of Waterloo, 2014-02-25)Soil represents the largest global reservoir of microbial diversity for the discovery of novel genes and enzymes. Both stable-isotope probing (SIP) and metagenomics have been used to access uncultured microbial diversity, ... -
Targeting p62 Palmitoylation as a Potential Therapeutic Strategy towards Huntington Disease
(University of Waterloo, 2023-10-18)Huntington’s Disease (HD) is a neurodegenerative disorder caused by a mutation in the huntingtin gene leading to the accumulation of mutant huntingtin (mHTT) protein and disruption of many cellular pathways causing neuronal ... -
Temperatures Experienced by Emerald Ash Borer and Other Wood-boring Beetles in the Under-bark Microclimate
(University of Waterloo, 2011-09-30)Most studies of under-bark microclimate have been restricted to observations of a few coniferous trees in wooded southern latitudes. This limitation is worrying because of emerging wood-boring pests that specialize on ... -
Testate Amoebae as a Performance Indicator of Ecosystem Establishment in Wetlands Impacted By Oil Sands Processed Materials
(University of Waterloo, 2009-05-14)Mining for oil sands in the Athabasca Basin in northeastern Alberta is rapidly expanding. As economics continue to drive growing mining practices, waste management, reclamation and bio-monitoring strategies are becoming ... -
The therapeutic application of Pituitary Adenylate Cyclase-Activating Polypeptide and double stranded (ds)RNA as immunostimulants and antiviral agents in crustaceans
(University of Waterloo, 2022-05-16)Currently valued at 28 billion USD per year, the global shrimp market is growing faster than any other aquaculture industry. The initial fast-paced global industry expansion led to many catastrophic viral shrimp pandemics. ... -
Tissue storage affects lipidome profiling in comparison to in vivo microsampling approach
(Springer, 2018-05-03)Low-invasive in vivo solid-phase microextraction (SPME) was used to investigate the lipid profiles of muscle tissue of living fish. Briefly, mixed mode SPME fibers were inserted into the muscle for 20 min extraction, and ... -
Towards the Production of the Haemophilus influenzae IgA1 protease in Escherichia coli
(University of Waterloo, 2014-12-12)H. influenzae is a gram-negative bacterium colonizing the human respiratory tract and is responsible for hundreds of thousands of deaths annually. To aid in persistence and infection in its human host H. influenzae produces ... -
Toxicity and bioaccumulation kinetics of cadmium and potassium permanganate in two clades within the 𝘏𝘺𝘢𝘭𝘦𝘭𝘭𝘢 𝘢𝘻𝘵𝘦𝘤𝘢 species complex
(University of Waterloo, 2019-09-12)The freshwater amphipod 𝘏𝘺𝘢𝘭𝘦𝘭𝘭𝘢 𝘢𝘻𝘵𝘦𝘤𝘢 has been frequently used in toxicology since the 1980s due to its general sensitivity, ease of culture, and North America-wide geographic range. Over the past 20 years, ... -
Toxicity Assessment of Oil Sands Process-Affected Water Using Fish Cell Lines
(University of Waterloo, 2010-09-28)Toxicity assessment of large numbers of oil sands process-affected waters (OSPW) are needed in order to reclaim mined oil sands aquatic reclamation scenarios, such as End Pit Lakes (EPLs). Conventional toxicity testing ... -
Toxicity Assessment of PAHs and Metals to Bacteria and the Roles of Soil Bacteria in Phytoremediation of Petroleum Hydrocarbons
(University of Waterloo, 2008-09-26)Petroleum hydrocarbons (PHCs) are a class of ubiquitous contaminants in the environment. PHCs impact to soil and water occur at well sites, refineries, service stations, and other facilities. Petroleum processing and ... -
Tracing the molecular and evolutionary determinants of novel functions in protein families
(University of Waterloo, 2010-03-29)This thesis explores the limits of homology-based inference of protein function and evolution, where overall similarity between sequences can be a poor indicator of functional similarity or evolutionary relationships. Each ... -
Traditional Methods and New Fluorometric Methods to Determine Phytoplankton Nutrient Status for Freshwater Ecosystems, and Their Application in the Lower Laurentian Great Lakes
(University of Waterloo, 2009-10-01)The Laurentian Great Lakes are the largest system of freshwater on earth containing 22% of the world’s supply. Although part of a single system, each lake shows substantial variation regarding physical, chemical and ... -
Transcriptional regulation of North American wood frog (Rana sylvatica) dorsal skin during development and in response to chronic exposure to a microplastics mixture
(University of Waterloo, 2024-02-09)Amphibian populations have been experiencing declines globally for decades due to factors such as habitat loss, invasive species, climate change, overexploitation, pollution, and disease. Skin is an important immune organ ... -
Trophic disruption effects on the diet and condition of Lake Whitefish
(University of Waterloo, 2010-01-18)Recently, the growth and condition of Lake Whitefish (Coregonus clupeaformis), an important commercial fishery commodity, has declined in some areas of the Great Lakes. As Lake Whitefish are benthic feeders, historically ... -
Two Dimensional Genetic Approach to the Development of a Controllable Lytic Phage Display System
(University of Waterloo, 2013-02-22)Bacteriophage Lambda (λ) has played a historical role as an essential model contributing to our current understanding of molecular genetics. Lambda’s major capsid protein “gpD” occurs on each capsid at 405 to 420 copies ... -
Two of the Mechanims Used by Bacteria to Modify the Environment: Quorum Sensing and ACC Deaminase
(University of Waterloo, 2009-10-27)Quorum sensing (QS) cell-cell communication systems are utilized by bacteria to coordinate their behaviour according to cell density. Several different types of QS signal molecules have been identified, among which ... -
Understanding acute stress-mediated immunity in teleost fish
(Elsevier, 2021-12)The abilities and ways in which organisms respond to stress have long been demonstrated to affect the immune response of the organism. In mammalian studies, researchers have observed that chronic/long-term stress has a ... -
Understanding species life-history and ecology for improved conservation and recovery of the threatened Silver Shiner, Notropis photogenis
(University of Waterloo, 2022-06-03)Conservation and recovery strategies are typically developed with the best available information. However, for many imperilled small-bodied freshwater fish species there is often a lack of basic information available on ...